VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

The specific role of VEGFA-induced permeability and vascular leakage in physiology and pathology has remained unclear. Here we show that VEGFA-induced vascular leakage depends on signalling initiated via the VEGFR2 phosphosite Y949, regulating dynamic c-Src and VE-cadherin phosphorylation. Abolished...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Xiujuan, Padhan, Narendra, Sjöström, Elisabet O., Roche, Francis P., Testini, Chiara, Honkura, Naoki, Sáinz-Jaspeado, Miguel, Gordon, Emma, Bentley, Katie, Philippides, Andrew, Tolmachev, Vladimir, Dejana, Elisabetta, Stan, Radu V., Vestweber, Dietmar, Ballmer-Hofer, Kurt, Betsholtz, Christer, Pietras, Kristian, Jansson, Leif, Claesson-Welsh, Lena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814575/
https://www.ncbi.nlm.nih.gov/pubmed/27005951
http://dx.doi.org/10.1038/ncomms11017

Ejemplares similares

Ejemplares similares