The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases

Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effe...

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Detalles Bibliográficos
Autores principales: Raker, Verena Katharina, Becker, Christian, Steinbrink, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814577/
https://www.ncbi.nlm.nih.gov/pubmed/27065076
http://dx.doi.org/10.3389/fimmu.2016.00123
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author Raker, Verena Katharina
Becker, Christian
Steinbrink, Kerstin
author_facet Raker, Verena Katharina
Becker, Christian
Steinbrink, Kerstin
author_sort Raker, Verena Katharina
collection PubMed
description Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders. Here, we provide an overview of the cyclic AMP axis and its role as a regulator of immune functions and discuss the clinical and translational relevance of interventions with these processes.
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spelling pubmed-48145772016-04-08 The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases Raker, Verena Katharina Becker, Christian Steinbrink, Kerstin Front Immunol Immunology Nucleotide signaling molecules contribute to the regulation of cellular pathways. In the immune system, cyclic adenosine monophosphate (cAMP) is well established as a potent regulator of innate and adaptive immune cell functions. Therapeutic strategies to interrupt or enhance cAMP generation or effects have immunoregulatory potential in autoimmune and inflammatory disorders. Here, we provide an overview of the cyclic AMP axis and its role as a regulator of immune functions and discuss the clinical and translational relevance of interventions with these processes. Frontiers Media S.A. 2016-03-31 /pmc/articles/PMC4814577/ /pubmed/27065076 http://dx.doi.org/10.3389/fimmu.2016.00123 Text en Copyright © 2016 Raker, Becker and Steinbrink. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Raker, Verena Katharina
Becker, Christian
Steinbrink, Kerstin
The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
title The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
title_full The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
title_fullStr The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
title_full_unstemmed The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
title_short The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases
title_sort camp pathway as therapeutic target in autoimmune and inflammatory diseases
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814577/
https://www.ncbi.nlm.nih.gov/pubmed/27065076
http://dx.doi.org/10.3389/fimmu.2016.00123
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