Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease

Quantitative electroencephalography (qEEG) showed that Alzheimer's disease (AD) is characterized by increased theta power, decreased alpha and beta power, and decreased coherence in the alpha and theta band in posterior regions. These abnormalities are thought to be associated with functional d...

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Autores principales: Marceglia, Sara, Mrakic-Sposta, Simona, Rosa, Manuela, Ferrucci, Roberta, Mameli, Francesca, Vergari, Maurizio, Arlotti, Mattia, Ruggiero, Fabiana, Scarpini, Elio, Galimberti, Daniela, Barbieri, Sergio, Priori, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814712/
https://www.ncbi.nlm.nih.gov/pubmed/27065792
http://dx.doi.org/10.3389/fnins.2016.00134
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author Marceglia, Sara
Mrakic-Sposta, Simona
Rosa, Manuela
Ferrucci, Roberta
Mameli, Francesca
Vergari, Maurizio
Arlotti, Mattia
Ruggiero, Fabiana
Scarpini, Elio
Galimberti, Daniela
Barbieri, Sergio
Priori, Alberto
author_facet Marceglia, Sara
Mrakic-Sposta, Simona
Rosa, Manuela
Ferrucci, Roberta
Mameli, Francesca
Vergari, Maurizio
Arlotti, Mattia
Ruggiero, Fabiana
Scarpini, Elio
Galimberti, Daniela
Barbieri, Sergio
Priori, Alberto
author_sort Marceglia, Sara
collection PubMed
description Quantitative electroencephalography (qEEG) showed that Alzheimer's disease (AD) is characterized by increased theta power, decreased alpha and beta power, and decreased coherence in the alpha and theta band in posterior regions. These abnormalities are thought to be associated with functional disconnections among cortical areas, death of cortical neurons, axonal pathology, and cholinergic deficits. Since transcranial Direct Current Stimulation (tDCS) over the temporo-parietal area is thought to have beneficial effects in patients with AD, in this study we aimed to investigate whether tDCS benefits are related to tDCS-induced changes in cortical activity, as represented by qEEG. A weak anodal current (1.5 mA, 15 min) was delivered bilaterally over the temporal-parietal lobe to seven subjects with probable AD (Mini-Mental State Examination, MMSE score >20). EEG (21 electrodes, 10–20 international system) was recorded for 5 min with eyes closed before (baseline, t0) and 30 min after anodal and cathodal tDCS ended (t1). At the same time points, patients performed a Word Recognition Task (WRT) to assess working memory functions. The spectral power and the inter- and intra-hemispheric EEG coherence in different frequency bands (e.g., low frequencies, including delta and theta; high frequencies, including alpha and beta) were calculated for each subject at t0 and t1. tDCS-induced changes in EEG neurophysiological markers were correlated with the performance of patients at the WRT. At baseline, qEEG features in AD patients confirmed that the decreased high frequency power was correlated with lower MMSE. After anodal tDCS, we observed an increase in the high-frequency power in the temporo-parietal area and an increase in the temporo-parieto-occipital coherence that correlated with the improvement at the WRT. In addition, cathodal tDCS produced a non-specific effect of decreased theta power all over the scalp that was not correlated with the clinical observation at the WRT. Our findings disclosed that tDCS induces significant modulations in the cortical EEG activity in AD patients. The abnormal pattern of EEG activity observed in AD during memory processing is partially reversed by applying anodal tDCS, suggesting that anodal tDCS benefits in AD patients during working memory tasks are supported by the modulation of cortical activity.
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spelling pubmed-48147122016-04-08 Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease Marceglia, Sara Mrakic-Sposta, Simona Rosa, Manuela Ferrucci, Roberta Mameli, Francesca Vergari, Maurizio Arlotti, Mattia Ruggiero, Fabiana Scarpini, Elio Galimberti, Daniela Barbieri, Sergio Priori, Alberto Front Neurosci Psychiatry Quantitative electroencephalography (qEEG) showed that Alzheimer's disease (AD) is characterized by increased theta power, decreased alpha and beta power, and decreased coherence in the alpha and theta band in posterior regions. These abnormalities are thought to be associated with functional disconnections among cortical areas, death of cortical neurons, axonal pathology, and cholinergic deficits. Since transcranial Direct Current Stimulation (tDCS) over the temporo-parietal area is thought to have beneficial effects in patients with AD, in this study we aimed to investigate whether tDCS benefits are related to tDCS-induced changes in cortical activity, as represented by qEEG. A weak anodal current (1.5 mA, 15 min) was delivered bilaterally over the temporal-parietal lobe to seven subjects with probable AD (Mini-Mental State Examination, MMSE score >20). EEG (21 electrodes, 10–20 international system) was recorded for 5 min with eyes closed before (baseline, t0) and 30 min after anodal and cathodal tDCS ended (t1). At the same time points, patients performed a Word Recognition Task (WRT) to assess working memory functions. The spectral power and the inter- and intra-hemispheric EEG coherence in different frequency bands (e.g., low frequencies, including delta and theta; high frequencies, including alpha and beta) were calculated for each subject at t0 and t1. tDCS-induced changes in EEG neurophysiological markers were correlated with the performance of patients at the WRT. At baseline, qEEG features in AD patients confirmed that the decreased high frequency power was correlated with lower MMSE. After anodal tDCS, we observed an increase in the high-frequency power in the temporo-parietal area and an increase in the temporo-parieto-occipital coherence that correlated with the improvement at the WRT. In addition, cathodal tDCS produced a non-specific effect of decreased theta power all over the scalp that was not correlated with the clinical observation at the WRT. Our findings disclosed that tDCS induces significant modulations in the cortical EEG activity in AD patients. The abnormal pattern of EEG activity observed in AD during memory processing is partially reversed by applying anodal tDCS, suggesting that anodal tDCS benefits in AD patients during working memory tasks are supported by the modulation of cortical activity. Frontiers Media S.A. 2016-03-31 /pmc/articles/PMC4814712/ /pubmed/27065792 http://dx.doi.org/10.3389/fnins.2016.00134 Text en Copyright © 2016 Marceglia, Mrakic-Sposta, Rosa, Ferrucci, Mameli, Vergari, Arlotti, Ruggiero, Scarpini, Galimberti, Barbieri and Priori. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Marceglia, Sara
Mrakic-Sposta, Simona
Rosa, Manuela
Ferrucci, Roberta
Mameli, Francesca
Vergari, Maurizio
Arlotti, Mattia
Ruggiero, Fabiana
Scarpini, Elio
Galimberti, Daniela
Barbieri, Sergio
Priori, Alberto
Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease
title Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease
title_full Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease
title_fullStr Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease
title_full_unstemmed Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease
title_short Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease
title_sort transcranial direct current stimulation modulates cortical neuronal activity in alzheimer's disease
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814712/
https://www.ncbi.nlm.nih.gov/pubmed/27065792
http://dx.doi.org/10.3389/fnins.2016.00134
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