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Reproductive Neuroendocrine Pathways of Social Behavior

Social behaviors are key components of reproduction, because they are essential for successful fertilization. Social behaviors, such as courtship, mating, and aggression, are strongly associated with sex steroids, such as testosterone, estradiol, and progesterone. Secretion of sex steroids from the...

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Autores principales: Parhar, Ishwar S., Ogawa, Satoshi, Ubuka, Takayoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814763/
https://www.ncbi.nlm.nih.gov/pubmed/27065948
http://dx.doi.org/10.3389/fendo.2016.00028
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author Parhar, Ishwar S.
Ogawa, Satoshi
Ubuka, Takayoshi
author_facet Parhar, Ishwar S.
Ogawa, Satoshi
Ubuka, Takayoshi
author_sort Parhar, Ishwar S.
collection PubMed
description Social behaviors are key components of reproduction, because they are essential for successful fertilization. Social behaviors, such as courtship, mating, and aggression, are strongly associated with sex steroids, such as testosterone, estradiol, and progesterone. Secretion of sex steroids from the gonads is regulated by the hypothalamus–pituitary–gonadal (HPG) axis in vertebrates. Gonadotropin-releasing hormone (GnRH) is a pivotal hypothalamic neuropeptide that stimulates gonadotropin release from the pituitary. In recent years, the role of neuropeptides containing the C-terminal Arg–Phe–NH(2) (RFamide peptides) has been emphasized in vertebrate reproduction. In particular, two key RFamide peptides, kisspeptin and gonadotropin-inhibitory hormone (GnIH), emerged as critical accelerator and suppressor of gonadotropin secretion. Kisspeptin stimulates GnRH release by directly acting on GnRH neurons, whereas GnIH inhibits gonadotropin release by inhibiting kisspeptin, GnRH neurons, or pituitary gonadotropes. These neuropeptides can regulate social behavior by regulating the HPG axis. However, distribution of neuronal fibers of GnRH, kisspeptin, and GnIH neurons is not limited within the hypothalamus, and the existence of extrahypothalamic neuronal fibers suggests direct control of social behavior within the brain. It has traditionally been shown that central administration of GnRH can stimulate female sexual behavior in rats. Recently, it was shown that Kiss1, one of the paralogs of kisspeptin peptide family, regulates fear responses in zebrafish and GnIH inhibits sociosexual behavior in birds. Here, we highlight recent findings regarding the role of GnRH, kisspeptin, and GnIH in the regulation of social behaviors in fish, birds, and mammals and discuss their importance in future biological and biomedical research.
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spelling pubmed-48147632016-04-08 Reproductive Neuroendocrine Pathways of Social Behavior Parhar, Ishwar S. Ogawa, Satoshi Ubuka, Takayoshi Front Endocrinol (Lausanne) Endocrinology Social behaviors are key components of reproduction, because they are essential for successful fertilization. Social behaviors, such as courtship, mating, and aggression, are strongly associated with sex steroids, such as testosterone, estradiol, and progesterone. Secretion of sex steroids from the gonads is regulated by the hypothalamus–pituitary–gonadal (HPG) axis in vertebrates. Gonadotropin-releasing hormone (GnRH) is a pivotal hypothalamic neuropeptide that stimulates gonadotropin release from the pituitary. In recent years, the role of neuropeptides containing the C-terminal Arg–Phe–NH(2) (RFamide peptides) has been emphasized in vertebrate reproduction. In particular, two key RFamide peptides, kisspeptin and gonadotropin-inhibitory hormone (GnIH), emerged as critical accelerator and suppressor of gonadotropin secretion. Kisspeptin stimulates GnRH release by directly acting on GnRH neurons, whereas GnIH inhibits gonadotropin release by inhibiting kisspeptin, GnRH neurons, or pituitary gonadotropes. These neuropeptides can regulate social behavior by regulating the HPG axis. However, distribution of neuronal fibers of GnRH, kisspeptin, and GnIH neurons is not limited within the hypothalamus, and the existence of extrahypothalamic neuronal fibers suggests direct control of social behavior within the brain. It has traditionally been shown that central administration of GnRH can stimulate female sexual behavior in rats. Recently, it was shown that Kiss1, one of the paralogs of kisspeptin peptide family, regulates fear responses in zebrafish and GnIH inhibits sociosexual behavior in birds. Here, we highlight recent findings regarding the role of GnRH, kisspeptin, and GnIH in the regulation of social behaviors in fish, birds, and mammals and discuss their importance in future biological and biomedical research. Frontiers Media S.A. 2016-03-31 /pmc/articles/PMC4814763/ /pubmed/27065948 http://dx.doi.org/10.3389/fendo.2016.00028 Text en Copyright © 2016 Parhar, Ogawa and Ubuka. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Parhar, Ishwar S.
Ogawa, Satoshi
Ubuka, Takayoshi
Reproductive Neuroendocrine Pathways of Social Behavior
title Reproductive Neuroendocrine Pathways of Social Behavior
title_full Reproductive Neuroendocrine Pathways of Social Behavior
title_fullStr Reproductive Neuroendocrine Pathways of Social Behavior
title_full_unstemmed Reproductive Neuroendocrine Pathways of Social Behavior
title_short Reproductive Neuroendocrine Pathways of Social Behavior
title_sort reproductive neuroendocrine pathways of social behavior
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814763/
https://www.ncbi.nlm.nih.gov/pubmed/27065948
http://dx.doi.org/10.3389/fendo.2016.00028
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