Cargando…
Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis
Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization in infants worldwide. It is recognized by Toll‐like receptor 4 (TLR 4) and cluster of differentiation 14 (CD14) in the innate immune response. Previous case–control studies reported the influence of TLR4 Asp299Gly, TLR4...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814857/ https://www.ncbi.nlm.nih.gov/pubmed/26901241 http://dx.doi.org/10.1111/irv.12378 |
_version_ | 1782424489876783104 |
---|---|
author | Zhou, Jiahui Zhang, Xiangning Liu, Shuming Wang, Ziyou Chen, Qicong Wu, Yongfu He, Zhiwei Huang, Zunnan |
author_facet | Zhou, Jiahui Zhang, Xiangning Liu, Shuming Wang, Ziyou Chen, Qicong Wu, Yongfu He, Zhiwei Huang, Zunnan |
author_sort | Zhou, Jiahui |
collection | PubMed |
description | Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization in infants worldwide. It is recognized by Toll‐like receptor 4 (TLR 4) and cluster of differentiation 14 (CD14) in the innate immune response. Previous case–control studies reported the influence of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms on the risk of severe RSV infection. However, a decisive conclusion has not been achieved. Therefore, we performed this meta‐analysis to examine the association between these three polymorphisms and the development of RSV bronchiolitis. A systematic literature search was performed using the PubMed, EMbase, Google Scholar Search, China National Knowledge Infrastructure, China Biological Medicine, and Wanfang Databases. The data were extracted and pooled odds ratios with 95% confidence intervals were calculated under six genetic models. A total of six studies with 1009 cases and 1348 controls, three studies with 473 cases and 481 controls, or four studies with 325 cases and 650 controls relating to each of the three polymorphisms were included in this meta‐analysis. The analyzed data indicated that all of these polymorphisms were not associated with the risk of severe RSV infection. This is the first meta‐analysis to investigate the relationship of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection. Although the results of this retrospective analysis indicated a lack of the association, more extensive multicentric studies with large sample sizes are necessary to provide a more reliable estimation of the association between these three polymorphisms and RSV bronchiolitis susceptibility. |
format | Online Article Text |
id | pubmed-4814857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48148572016-05-01 Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis Zhou, Jiahui Zhang, Xiangning Liu, Shuming Wang, Ziyou Chen, Qicong Wu, Yongfu He, Zhiwei Huang, Zunnan Influenza Other Respir Viruses Review Article Respiratory syncytial virus (RSV) is the most frequent cause of hospitalization in infants worldwide. It is recognized by Toll‐like receptor 4 (TLR 4) and cluster of differentiation 14 (CD14) in the innate immune response. Previous case–control studies reported the influence of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms on the risk of severe RSV infection. However, a decisive conclusion has not been achieved. Therefore, we performed this meta‐analysis to examine the association between these three polymorphisms and the development of RSV bronchiolitis. A systematic literature search was performed using the PubMed, EMbase, Google Scholar Search, China National Knowledge Infrastructure, China Biological Medicine, and Wanfang Databases. The data were extracted and pooled odds ratios with 95% confidence intervals were calculated under six genetic models. A total of six studies with 1009 cases and 1348 controls, three studies with 473 cases and 481 controls, or four studies with 325 cases and 650 controls relating to each of the three polymorphisms were included in this meta‐analysis. The analyzed data indicated that all of these polymorphisms were not associated with the risk of severe RSV infection. This is the first meta‐analysis to investigate the relationship of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection. Although the results of this retrospective analysis indicated a lack of the association, more extensive multicentric studies with large sample sizes are necessary to provide a more reliable estimation of the association between these three polymorphisms and RSV bronchiolitis susceptibility. John Wiley and Sons Inc. 2016-03-07 2016-05 /pmc/articles/PMC4814857/ /pubmed/26901241 http://dx.doi.org/10.1111/irv.12378 Text en © 2016 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhou, Jiahui Zhang, Xiangning Liu, Shuming Wang, Ziyou Chen, Qicong Wu, Yongfu He, Zhiwei Huang, Zunnan Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis |
title | Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis |
title_full | Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis |
title_fullStr | Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis |
title_full_unstemmed | Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis |
title_short | Genetic association of TLR4 Asp299Gly, TLR4 Thr399Ile, and CD14 C‐159T polymorphisms with the risk of severe RSV infection: a meta‐analysis |
title_sort | genetic association of tlr4 asp299gly, tlr4 thr399ile, and cd14 c‐159t polymorphisms with the risk of severe rsv infection: a meta‐analysis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814857/ https://www.ncbi.nlm.nih.gov/pubmed/26901241 http://dx.doi.org/10.1111/irv.12378 |
work_keys_str_mv | AT zhoujiahui geneticassociationoftlr4asp299glytlr4thr399ileandcd14c159tpolymorphismswiththeriskofseverersvinfectionametaanalysis AT zhangxiangning geneticassociationoftlr4asp299glytlr4thr399ileandcd14c159tpolymorphismswiththeriskofseverersvinfectionametaanalysis AT liushuming geneticassociationoftlr4asp299glytlr4thr399ileandcd14c159tpolymorphismswiththeriskofseverersvinfectionametaanalysis AT wangziyou geneticassociationoftlr4asp299glytlr4thr399ileandcd14c159tpolymorphismswiththeriskofseverersvinfectionametaanalysis AT chenqicong geneticassociationoftlr4asp299glytlr4thr399ileandcd14c159tpolymorphismswiththeriskofseverersvinfectionametaanalysis AT wuyongfu geneticassociationoftlr4asp299glytlr4thr399ileandcd14c159tpolymorphismswiththeriskofseverersvinfectionametaanalysis AT hezhiwei geneticassociationoftlr4asp299glytlr4thr399ileandcd14c159tpolymorphismswiththeriskofseverersvinfectionametaanalysis AT huangzunnan geneticassociationoftlr4asp299glytlr4thr399ileandcd14c159tpolymorphismswiththeriskofseverersvinfectionametaanalysis |