Targeting dendritic cells: a promising strategy to improve vaccine effectiveness

Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of DCs. Here we review the complexity of the DC subsets and the antigen prese...

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Autores principales: Macri, Christophe, Dumont, Claire, Johnston, Angus PR, Mintern, Justine D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815026/
https://www.ncbi.nlm.nih.gov/pubmed/27217957
http://dx.doi.org/10.1038/cti.2016.6
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author Macri, Christophe
Dumont, Claire
Johnston, Angus PR
Mintern, Justine D
author_facet Macri, Christophe
Dumont, Claire
Johnston, Angus PR
Mintern, Justine D
author_sort Macri, Christophe
collection PubMed
description Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of DCs. Here we review the complexity of the DC subsets and the antigen presentation pathways that need to be considered in the settings of DC targeting. We also summarize current knowledge about antigen delivery to DCs via DEC-205, Clec9A and Clec12A, receptor targets that strongly enhance cellular and humoral immune responses. Finally, we discuss the intracellular trafficking criteria of the targeted receptors that may impact their effectiveness as DC targets.
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spelling pubmed-48150262016-05-23 Targeting dendritic cells: a promising strategy to improve vaccine effectiveness Macri, Christophe Dumont, Claire Johnston, Angus PR Mintern, Justine D Clin Transl Immunology Review Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This approach is based on the in situ delivery of antigen via antibodies that are specific for endocytic receptors expressed at the surface of DCs. Here we review the complexity of the DC subsets and the antigen presentation pathways that need to be considered in the settings of DC targeting. We also summarize current knowledge about antigen delivery to DCs via DEC-205, Clec9A and Clec12A, receptor targets that strongly enhance cellular and humoral immune responses. Finally, we discuss the intracellular trafficking criteria of the targeted receptors that may impact their effectiveness as DC targets. Nature Publishing Group 2016-03-18 /pmc/articles/PMC4815026/ /pubmed/27217957 http://dx.doi.org/10.1038/cti.2016.6 Text en Copyright © 2016 Australasian Society for Immunology Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Review
Macri, Christophe
Dumont, Claire
Johnston, Angus PR
Mintern, Justine D
Targeting dendritic cells: a promising strategy to improve vaccine effectiveness
title Targeting dendritic cells: a promising strategy to improve vaccine effectiveness
title_full Targeting dendritic cells: a promising strategy to improve vaccine effectiveness
title_fullStr Targeting dendritic cells: a promising strategy to improve vaccine effectiveness
title_full_unstemmed Targeting dendritic cells: a promising strategy to improve vaccine effectiveness
title_short Targeting dendritic cells: a promising strategy to improve vaccine effectiveness
title_sort targeting dendritic cells: a promising strategy to improve vaccine effectiveness
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815026/
https://www.ncbi.nlm.nih.gov/pubmed/27217957
http://dx.doi.org/10.1038/cti.2016.6
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