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Essential role for SphK1/S1P signaling to regulate hypoxia-inducible factor 2α expression and activity in cancer

The sphingosine kinase-1/sphingosine 1-phosphate (SphK1/S1P) signaling pathway has been reported to modulate the expression of the canonical transcription factor hypoxia-inducible HIF-1α in multiple cell lineages. HIF-2α is also frequently overexpressed in solid tumors but its role has been mostly s...

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Detalles Bibliográficos
Autores principales:	Bouquerel, P, Gstalder, C, Müller, D, Laurent, J, Brizuela, L, Sabbadini, R A, Malavaud, B, Pyronnet, S, Martineau, Y, Ader, I, Cuvillier, O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815047/ https://www.ncbi.nlm.nih.gov/pubmed/26974204 http://dx.doi.org/10.1038/oncsis.2016.13

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