The cytokine interleukin-26 as a biomarker in pediatric asthma

In this pilot study, we examined associations between local interleukin (IL)-26, disease severity and biomarkers of Th2-mediated inflammation in a well-defined cohort of pediatric patients (14 years median age, 41 % females) with controlled (n = 28) or uncontrolled (n = 48) asthma. Sputum IL-26 prot...

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Autores principales: Konradsen, Jon R., Nordlund, Björn, Levänen, Bettina, Hedlin, Gunilla, Linden, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815075/
https://www.ncbi.nlm.nih.gov/pubmed/27029915
http://dx.doi.org/10.1186/s12931-016-0351-6
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author Konradsen, Jon R.
Nordlund, Björn
Levänen, Bettina
Hedlin, Gunilla
Linden, Anders
author_facet Konradsen, Jon R.
Nordlund, Björn
Levänen, Bettina
Hedlin, Gunilla
Linden, Anders
author_sort Konradsen, Jon R.
collection PubMed
description In this pilot study, we examined associations between local interleukin (IL)-26, disease severity and biomarkers of Th2-mediated inflammation in a well-defined cohort of pediatric patients (14 years median age, 41 % females) with controlled (n = 28) or uncontrolled (n = 48) asthma. Sputum IL-26 protein concentrations (ELISA) reflected disease control in patients without local (low exhaled nitric oxide) or systemic (low blood eosinophils) signs of eosinophilic inflammation. Moreover, sputum-IL-26 concentrations correlated with those of blood neutrophils. Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation.
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spelling pubmed-48150752016-04-01 The cytokine interleukin-26 as a biomarker in pediatric asthma Konradsen, Jon R. Nordlund, Björn Levänen, Bettina Hedlin, Gunilla Linden, Anders Respir Res Letter to the Editor In this pilot study, we examined associations between local interleukin (IL)-26, disease severity and biomarkers of Th2-mediated inflammation in a well-defined cohort of pediatric patients (14 years median age, 41 % females) with controlled (n = 28) or uncontrolled (n = 48) asthma. Sputum IL-26 protein concentrations (ELISA) reflected disease control in patients without local (low exhaled nitric oxide) or systemic (low blood eosinophils) signs of eosinophilic inflammation. Moreover, sputum-IL-26 concentrations correlated with those of blood neutrophils. Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation. BioMed Central 2016-03-31 2016 /pmc/articles/PMC4815075/ /pubmed/27029915 http://dx.doi.org/10.1186/s12931-016-0351-6 Text en © Konradsen et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Konradsen, Jon R.
Nordlund, Björn
Levänen, Bettina
Hedlin, Gunilla
Linden, Anders
The cytokine interleukin-26 as a biomarker in pediatric asthma
title The cytokine interleukin-26 as a biomarker in pediatric asthma
title_full The cytokine interleukin-26 as a biomarker in pediatric asthma
title_fullStr The cytokine interleukin-26 as a biomarker in pediatric asthma
title_full_unstemmed The cytokine interleukin-26 as a biomarker in pediatric asthma
title_short The cytokine interleukin-26 as a biomarker in pediatric asthma
title_sort cytokine interleukin-26 as a biomarker in pediatric asthma
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815075/
https://www.ncbi.nlm.nih.gov/pubmed/27029915
http://dx.doi.org/10.1186/s12931-016-0351-6
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