Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone

Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic agents remai...

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Autores principales: Bernstock, Joshua D., Budinich, Craig S., Cohen, Leonardo G., Awosika, Oluwole O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815137/
https://www.ncbi.nlm.nih.gov/pubmed/27064505
http://dx.doi.org/10.3389/fneur.2016.00050
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author Bernstock, Joshua D.
Budinich, Craig S.
Cohen, Leonardo G.
Awosika, Oluwole O.
author_facet Bernstock, Joshua D.
Budinich, Craig S.
Cohen, Leonardo G.
Awosika, Oluwole O.
author_sort Bernstock, Joshua D.
collection PubMed
description Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic agents remain unknown. Accordingly, herein, we report a unique case of a patient with hydromorphone-induced recrudescence 30 years after her initial stroke event(s) and in so doing propose a putative mechanism related to post-infarction functional neuroplasticity.
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spelling pubmed-48151372016-04-08 Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone Bernstock, Joshua D. Budinich, Craig S. Cohen, Leonardo G. Awosika, Oluwole O. Front Neurol Neuroscience Patients who have recovered from a prior stroke may experience a reemergence of their original stroke syndrome secondary to metabolic derangements, sedation, infection, and/or fatigue. Critically, the molecular/cellular mechanisms mediating symptom recurrence after exposure to analgesic agents remain unknown. Accordingly, herein, we report a unique case of a patient with hydromorphone-induced recrudescence 30 years after her initial stroke event(s) and in so doing propose a putative mechanism related to post-infarction functional neuroplasticity. Frontiers Media S.A. 2016-03-31 /pmc/articles/PMC4815137/ /pubmed/27064505 http://dx.doi.org/10.3389/fneur.2016.00050 Text en Copyright © 2016 Bernstock, Budinich, Cohen and Awosika. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Bernstock, Joshua D.
Budinich, Craig S.
Cohen, Leonardo G.
Awosika, Oluwole O.
Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone
title Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone
title_full Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone
title_fullStr Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone
title_full_unstemmed Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone
title_short Recrudescence of Focal Stroke Symptoms during Pain Management with Hydromorphone
title_sort recrudescence of focal stroke symptoms during pain management with hydromorphone
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815137/
https://www.ncbi.nlm.nih.gov/pubmed/27064505
http://dx.doi.org/10.3389/fneur.2016.00050
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