Functional and genetic screening of acute myeloid leukemia associated with mediastinal germ cell tumor identifies MEK inhibitor as an active clinical agent

BACKGROUND: Hematologic malignancies arising in the setting of established germ cell tumors have been previously described and have a dismal prognosis. Identification of targetable mutations and pathway dysregulation through massively parallel sequencing and functional assays provides new approaches...

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Detalles Bibliográficos
Autores principales: Leonard, Jessica T., Raess, Philipp W., Dunlap, Jennifer, Hayes-Lattin, Brandon, Tyner, Jeffrey W., Traer, Elie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815159/
https://www.ncbi.nlm.nih.gov/pubmed/27036514
http://dx.doi.org/10.1186/s13045-016-0258-1

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