Cargando…

The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial

BACKGROUND: Recent investigations have identified that commercially available dietary supplements, containing a combination of thermogenic ingredients, can increase resting metabolic rate (RMR). Thermogenic dietary supplements can have a positive influence on RMR, but the magnitude can vary based on...

Descripción completa

Detalles Bibliográficos
Autores principales: Campbell, Bill I., Zito, Gina, Colquhoun, Ryan, Martinez, Nic, Kendall, Kristina, Buchanan, Laura, Lehn, Matt, Johnson, Mallory, St. Louis, Courtney, Smith, Yasmin, Cloer, Brad, Pingel, Allison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815210/
https://www.ncbi.nlm.nih.gov/pubmed/27034624
http://dx.doi.org/10.1186/s12970-016-0123-1
_version_ 1782424563312754688
author Campbell, Bill I.
Zito, Gina
Colquhoun, Ryan
Martinez, Nic
Kendall, Kristina
Buchanan, Laura
Lehn, Matt
Johnson, Mallory
St. Louis, Courtney
Smith, Yasmin
Cloer, Brad
Pingel, Allison
author_facet Campbell, Bill I.
Zito, Gina
Colquhoun, Ryan
Martinez, Nic
Kendall, Kristina
Buchanan, Laura
Lehn, Matt
Johnson, Mallory
St. Louis, Courtney
Smith, Yasmin
Cloer, Brad
Pingel, Allison
author_sort Campbell, Bill I.
collection PubMed
description BACKGROUND: Recent investigations have identified that commercially available dietary supplements, containing a combination of thermogenic ingredients, can increase resting metabolic rate (RMR). Thermogenic dietary supplements can have a positive influence on RMR, but the magnitude can vary based on the active ingredient and/or combination of active ingredients. Additionally, further safety evaluation is needed on multi-ingredient supplements that contain caffeine, due to its potential effect on heart rate (HR) and blood pressure (BP). The purpose of this study was to examine the effects of a commercially available dietary supplement on RMR and hemodynamic variables in healthy females. METHODS: 13 female participants (26.1 ± 11.3 years; 163.4 ± 9.1 cm; 63.7 ± 8.0 kg, and 24 ± 5 BMI) volunteered to participate in this investigation. Participants underwent two testing sessions separated by approximately 7 days. On their first visit, participants arrived to the laboratory after an overnight fast and underwent a baseline RMR, HR, and BP assessment. Next, each participant ingested a thermogenic dietary supplement or placebo and repeated the RMR, HR, and BP assessments at 60, 120, and 180-minutes post-ingestion. Approximately 1-week later, the alternative supplement was ingested and the assessments were repeated in the exact same manner. Data were analyzed via a 2-factor [2x4] within-subjects repeated measures analysis of variance (ANOVA). Post-hoc tests were analyzed via paired samples t-tests. RESULTS: Repeated measures ANOVA revealed a significant effect for time relative to raw RMR data. Post-hoc analysis revealed that the dietary supplement treatment significantly increased RMR at 60-minutes, 120-minutes, and 180-minutes post ingestion (p < 0.05) as compared to baseline RMR values. No changes in RMR were observed for the placebo treatment (p > 0.05). Heart rate was not significantly affected at any time point with either supplement; however, main effects of treatment and time were observed for both systolic and diastolic blood pressure (p < 0.05). CONCLUSIONS: The thermogenic dietary supplement treatment experienced greater elevations in RMR as compared to baseline. Due to the slight elevations in blood pressure, caution should be taken for those with increased risk for hypertension or pre-hypertension. Taken on a daily basis, thermogenic dietary supplementation may increase overall energy expenditure, potentially leading to reductions in fat mass over time.
format Online
Article
Text
id pubmed-4815210
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-48152102016-04-01 The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial Campbell, Bill I. Zito, Gina Colquhoun, Ryan Martinez, Nic Kendall, Kristina Buchanan, Laura Lehn, Matt Johnson, Mallory St. Louis, Courtney Smith, Yasmin Cloer, Brad Pingel, Allison J Int Soc Sports Nutr Research Article BACKGROUND: Recent investigations have identified that commercially available dietary supplements, containing a combination of thermogenic ingredients, can increase resting metabolic rate (RMR). Thermogenic dietary supplements can have a positive influence on RMR, but the magnitude can vary based on the active ingredient and/or combination of active ingredients. Additionally, further safety evaluation is needed on multi-ingredient supplements that contain caffeine, due to its potential effect on heart rate (HR) and blood pressure (BP). The purpose of this study was to examine the effects of a commercially available dietary supplement on RMR and hemodynamic variables in healthy females. METHODS: 13 female participants (26.1 ± 11.3 years; 163.4 ± 9.1 cm; 63.7 ± 8.0 kg, and 24 ± 5 BMI) volunteered to participate in this investigation. Participants underwent two testing sessions separated by approximately 7 days. On their first visit, participants arrived to the laboratory after an overnight fast and underwent a baseline RMR, HR, and BP assessment. Next, each participant ingested a thermogenic dietary supplement or placebo and repeated the RMR, HR, and BP assessments at 60, 120, and 180-minutes post-ingestion. Approximately 1-week later, the alternative supplement was ingested and the assessments were repeated in the exact same manner. Data were analyzed via a 2-factor [2x4] within-subjects repeated measures analysis of variance (ANOVA). Post-hoc tests were analyzed via paired samples t-tests. RESULTS: Repeated measures ANOVA revealed a significant effect for time relative to raw RMR data. Post-hoc analysis revealed that the dietary supplement treatment significantly increased RMR at 60-minutes, 120-minutes, and 180-minutes post ingestion (p < 0.05) as compared to baseline RMR values. No changes in RMR were observed for the placebo treatment (p > 0.05). Heart rate was not significantly affected at any time point with either supplement; however, main effects of treatment and time were observed for both systolic and diastolic blood pressure (p < 0.05). CONCLUSIONS: The thermogenic dietary supplement treatment experienced greater elevations in RMR as compared to baseline. Due to the slight elevations in blood pressure, caution should be taken for those with increased risk for hypertension or pre-hypertension. Taken on a daily basis, thermogenic dietary supplementation may increase overall energy expenditure, potentially leading to reductions in fat mass over time. BioMed Central 2016-03-31 /pmc/articles/PMC4815210/ /pubmed/27034624 http://dx.doi.org/10.1186/s12970-016-0123-1 Text en © Campbell et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Campbell, Bill I.
Zito, Gina
Colquhoun, Ryan
Martinez, Nic
Kendall, Kristina
Buchanan, Laura
Lehn, Matt
Johnson, Mallory
St. Louis, Courtney
Smith, Yasmin
Cloer, Brad
Pingel, Allison
The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial
title The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial
title_full The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial
title_fullStr The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial
title_full_unstemmed The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial
title_short The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial
title_sort effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815210/
https://www.ncbi.nlm.nih.gov/pubmed/27034624
http://dx.doi.org/10.1186/s12970-016-0123-1
work_keys_str_mv AT campbellbilli theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT zitogina theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT colquhounryan theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT martineznic theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT kendallkristina theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT buchananlaura theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT lehnmatt theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT johnsonmallory theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT stlouiscourtney theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT smithyasmin theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT cloerbrad theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT pingelallison theeffectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT campbellbilli effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT zitogina effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT colquhounryan effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT martineznic effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT kendallkristina effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT buchananlaura effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT lehnmatt effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT johnsonmallory effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT stlouiscourtney effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT smithyasmin effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT cloerbrad effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial
AT pingelallison effectsofasingledosethermogenicsupplementonrestingmetabolicrateandhemodynamicvariablesinhealthyfemalesarandomizeddoubleblindplacebocontrolledcrossovertrial