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The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial
BACKGROUND: Recent investigations have identified that commercially available dietary supplements, containing a combination of thermogenic ingredients, can increase resting metabolic rate (RMR). Thermogenic dietary supplements can have a positive influence on RMR, but the magnitude can vary based on...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815210/ https://www.ncbi.nlm.nih.gov/pubmed/27034624 http://dx.doi.org/10.1186/s12970-016-0123-1 |
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author | Campbell, Bill I. Zito, Gina Colquhoun, Ryan Martinez, Nic Kendall, Kristina Buchanan, Laura Lehn, Matt Johnson, Mallory St. Louis, Courtney Smith, Yasmin Cloer, Brad Pingel, Allison |
author_facet | Campbell, Bill I. Zito, Gina Colquhoun, Ryan Martinez, Nic Kendall, Kristina Buchanan, Laura Lehn, Matt Johnson, Mallory St. Louis, Courtney Smith, Yasmin Cloer, Brad Pingel, Allison |
author_sort | Campbell, Bill I. |
collection | PubMed |
description | BACKGROUND: Recent investigations have identified that commercially available dietary supplements, containing a combination of thermogenic ingredients, can increase resting metabolic rate (RMR). Thermogenic dietary supplements can have a positive influence on RMR, but the magnitude can vary based on the active ingredient and/or combination of active ingredients. Additionally, further safety evaluation is needed on multi-ingredient supplements that contain caffeine, due to its potential effect on heart rate (HR) and blood pressure (BP). The purpose of this study was to examine the effects of a commercially available dietary supplement on RMR and hemodynamic variables in healthy females. METHODS: 13 female participants (26.1 ± 11.3 years; 163.4 ± 9.1 cm; 63.7 ± 8.0 kg, and 24 ± 5 BMI) volunteered to participate in this investigation. Participants underwent two testing sessions separated by approximately 7 days. On their first visit, participants arrived to the laboratory after an overnight fast and underwent a baseline RMR, HR, and BP assessment. Next, each participant ingested a thermogenic dietary supplement or placebo and repeated the RMR, HR, and BP assessments at 60, 120, and 180-minutes post-ingestion. Approximately 1-week later, the alternative supplement was ingested and the assessments were repeated in the exact same manner. Data were analyzed via a 2-factor [2x4] within-subjects repeated measures analysis of variance (ANOVA). Post-hoc tests were analyzed via paired samples t-tests. RESULTS: Repeated measures ANOVA revealed a significant effect for time relative to raw RMR data. Post-hoc analysis revealed that the dietary supplement treatment significantly increased RMR at 60-minutes, 120-minutes, and 180-minutes post ingestion (p < 0.05) as compared to baseline RMR values. No changes in RMR were observed for the placebo treatment (p > 0.05). Heart rate was not significantly affected at any time point with either supplement; however, main effects of treatment and time were observed for both systolic and diastolic blood pressure (p < 0.05). CONCLUSIONS: The thermogenic dietary supplement treatment experienced greater elevations in RMR as compared to baseline. Due to the slight elevations in blood pressure, caution should be taken for those with increased risk for hypertension or pre-hypertension. Taken on a daily basis, thermogenic dietary supplementation may increase overall energy expenditure, potentially leading to reductions in fat mass over time. |
format | Online Article Text |
id | pubmed-4815210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48152102016-04-01 The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial Campbell, Bill I. Zito, Gina Colquhoun, Ryan Martinez, Nic Kendall, Kristina Buchanan, Laura Lehn, Matt Johnson, Mallory St. Louis, Courtney Smith, Yasmin Cloer, Brad Pingel, Allison J Int Soc Sports Nutr Research Article BACKGROUND: Recent investigations have identified that commercially available dietary supplements, containing a combination of thermogenic ingredients, can increase resting metabolic rate (RMR). Thermogenic dietary supplements can have a positive influence on RMR, but the magnitude can vary based on the active ingredient and/or combination of active ingredients. Additionally, further safety evaluation is needed on multi-ingredient supplements that contain caffeine, due to its potential effect on heart rate (HR) and blood pressure (BP). The purpose of this study was to examine the effects of a commercially available dietary supplement on RMR and hemodynamic variables in healthy females. METHODS: 13 female participants (26.1 ± 11.3 years; 163.4 ± 9.1 cm; 63.7 ± 8.0 kg, and 24 ± 5 BMI) volunteered to participate in this investigation. Participants underwent two testing sessions separated by approximately 7 days. On their first visit, participants arrived to the laboratory after an overnight fast and underwent a baseline RMR, HR, and BP assessment. Next, each participant ingested a thermogenic dietary supplement or placebo and repeated the RMR, HR, and BP assessments at 60, 120, and 180-minutes post-ingestion. Approximately 1-week later, the alternative supplement was ingested and the assessments were repeated in the exact same manner. Data were analyzed via a 2-factor [2x4] within-subjects repeated measures analysis of variance (ANOVA). Post-hoc tests were analyzed via paired samples t-tests. RESULTS: Repeated measures ANOVA revealed a significant effect for time relative to raw RMR data. Post-hoc analysis revealed that the dietary supplement treatment significantly increased RMR at 60-minutes, 120-minutes, and 180-minutes post ingestion (p < 0.05) as compared to baseline RMR values. No changes in RMR were observed for the placebo treatment (p > 0.05). Heart rate was not significantly affected at any time point with either supplement; however, main effects of treatment and time were observed for both systolic and diastolic blood pressure (p < 0.05). CONCLUSIONS: The thermogenic dietary supplement treatment experienced greater elevations in RMR as compared to baseline. Due to the slight elevations in blood pressure, caution should be taken for those with increased risk for hypertension or pre-hypertension. Taken on a daily basis, thermogenic dietary supplementation may increase overall energy expenditure, potentially leading to reductions in fat mass over time. BioMed Central 2016-03-31 /pmc/articles/PMC4815210/ /pubmed/27034624 http://dx.doi.org/10.1186/s12970-016-0123-1 Text en © Campbell et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Campbell, Bill I. Zito, Gina Colquhoun, Ryan Martinez, Nic Kendall, Kristina Buchanan, Laura Lehn, Matt Johnson, Mallory St. Louis, Courtney Smith, Yasmin Cloer, Brad Pingel, Allison The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial |
title | The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial |
title_full | The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial |
title_fullStr | The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial |
title_full_unstemmed | The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial |
title_short | The effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial |
title_sort | effects of a single-dose thermogenic supplement on resting metabolic rate and hemodynamic variables in healthy females - a randomized, double-blind, placebo-controlled, cross-over trial |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815210/ https://www.ncbi.nlm.nih.gov/pubmed/27034624 http://dx.doi.org/10.1186/s12970-016-0123-1 |
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