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Plasmodium falciparum chloroquine resistance transporter (PfCRT) isoforms PH1 and PH2 perturb vacuolar physiology

BACKGROUND: Recent work has perfected yeast-based methods for measuring drug transport by the Plasmodium falciparum chloroquine (CQ) resistance transporter (PfCRT). METHODS: The approach relies on inducible heterologous expression of PfCRT in Saccharomyces cerevisiae yeast. In these experiments sele...

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Detalles Bibliográficos
Autores principales: Callaghan, Paul S., Siriwardana, Amila, Hassett, Matthew R., Roepe, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815217/
https://www.ncbi.nlm.nih.gov/pubmed/27036417
http://dx.doi.org/10.1186/s12936-016-1238-1