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Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

BACKGROUND: DNA topoisomerase I (Top1) is a DNA unwinding protein and the specific target of the camptothecin class of chemotherapeutic drugs. One of these, irinotecan, acting through its active metabolite SN-38, is used in the treatment of metastatic colorectal cancer. However, resistance to irinot...

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Detalles Bibliográficos
Autores principales:	Jensen, Niels Frank, Agama, Keli, Roy, Amit, Smith, David Hersi, Pfister, Thomas D., Rømer, Maria Unni, Zhang, Hong-Liang, Doroshow, James H., Knudsen, Birgitta R., Stenvang, Jan, Brünner, Nils, Pommier, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815242/ https://www.ncbi.nlm.nih.gov/pubmed/27029323 http://dx.doi.org/10.1186/s13046-016-0335-x

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