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The Anti-fibrotic Actions of Relaxin Are Mediated Through a NO-sGC-cGMP-Dependent Pathway in Renal Myofibroblasts In Vitro and Enhanced by the NO Donor, Diethylamine NONOate

Introduction: The anti-fibrotic hormone, relaxin, has been inferred to disrupt transforming growth factor (TGF)-β1/Smad2 phosphorylation (pSmad2) signal transduction and promote collagen-degrading gelatinase activity via a nitric oxide (NO)-dependent pathway. Here, we determined the extent to which...

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Detalles Bibliográficos
Autores principales:	Wang, Chao, Kemp-Harper, Barbara K., Kocan, Martina, Ang, Sheng Yu, Hewitson, Tim D., Samuel, Chrishan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2016
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815292/ https://www.ncbi.nlm.nih.gov/pubmed/27065874 http://dx.doi.org/10.3389/fphar.2016.00091

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