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Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?

Most of the Human diseases affecting westernized countries are associated with dysbiosis and loss of microbial diversity in the gut microbiota. The Western way of life, with a wide use of antibiotics and other environmental triggers, may reduce the number of bacterial predators leading to a decrease...

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Detalles Bibliográficos
Autores principales: Mosca, Alexis, Leclerc, Marion, Hugot, Jean P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815357/
https://www.ncbi.nlm.nih.gov/pubmed/27065999
http://dx.doi.org/10.3389/fmicb.2016.00455
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author Mosca, Alexis
Leclerc, Marion
Hugot, Jean P.
author_facet Mosca, Alexis
Leclerc, Marion
Hugot, Jean P.
author_sort Mosca, Alexis
collection PubMed
description Most of the Human diseases affecting westernized countries are associated with dysbiosis and loss of microbial diversity in the gut microbiota. The Western way of life, with a wide use of antibiotics and other environmental triggers, may reduce the number of bacterial predators leading to a decrease in microbial diversity of the Human gut. We argue that this phenomenon is similar to the process of ecosystem impoverishment in macro ecology where human activity decreases ecological niches, the size of predator populations, and finally the biodiversity. Such pauperization is fundamental since it reverses the evolution processes, drives life backward into diminished complexity, stability, and adaptability. A simple therapeutic approach could thus be to reintroduce bacterial predators and restore a bacterial diversity of the host microbiota.
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spelling pubmed-48153572016-04-08 Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Mosca, Alexis Leclerc, Marion Hugot, Jean P. Front Microbiol Microbiology Most of the Human diseases affecting westernized countries are associated with dysbiosis and loss of microbial diversity in the gut microbiota. The Western way of life, with a wide use of antibiotics and other environmental triggers, may reduce the number of bacterial predators leading to a decrease in microbial diversity of the Human gut. We argue that this phenomenon is similar to the process of ecosystem impoverishment in macro ecology where human activity decreases ecological niches, the size of predator populations, and finally the biodiversity. Such pauperization is fundamental since it reverses the evolution processes, drives life backward into diminished complexity, stability, and adaptability. A simple therapeutic approach could thus be to reintroduce bacterial predators and restore a bacterial diversity of the host microbiota. Frontiers Media S.A. 2016-03-31 /pmc/articles/PMC4815357/ /pubmed/27065999 http://dx.doi.org/10.3389/fmicb.2016.00455 Text en Copyright © 2016 Mosca, Leclerc and Hugot. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Mosca, Alexis
Leclerc, Marion
Hugot, Jean P.
Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
title Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
title_full Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
title_fullStr Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
title_full_unstemmed Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
title_short Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
title_sort gut microbiota diversity and human diseases: should we reintroduce key predators in our ecosystem?
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815357/
https://www.ncbi.nlm.nih.gov/pubmed/27065999
http://dx.doi.org/10.3389/fmicb.2016.00455
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