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Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy

INTRODUCTION: The metabolic syndrome (MetS) is common in human immune deficiency virus (HIV)-infected individuals receiving highly active antiretroviral therapy (HAART). Immune deficiencies caused by HIV give rise to numerous opportunistic gastrointestinal pathogens such as Helicobacter pylori, the...

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Autores principales: Longo-Mbenza, Benjamin, Apalata, Teke, Longokolo, Murielle, Mbula Mambimbi, Marcel, Etienne, Mokondjimobe, Buassa-bu-Tsumbu, Baudouin, Gombet, Thierry, Ellenga, Bertrain, Milongo Dipa, Guy, Lukoki Luila, Evelyne, Nge Okwe, Augustin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Clinics Cardive Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815505/
https://www.ncbi.nlm.nih.gov/pubmed/25940117
http://dx.doi.org/10.5830/CVJA-2015-012
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author Longo-Mbenza, Benjamin
Apalata, Teke
Longokolo, Murielle
Mbula Mambimbi, Marcel
Etienne, Mokondjimobe
Buassa-bu-Tsumbu, Baudouin
Gombet, Thierry
Ellenga, Bertrain
Milongo Dipa, Guy
Lukoki Luila, Evelyne
Nge Okwe, Augustin
author_facet Longo-Mbenza, Benjamin
Apalata, Teke
Longokolo, Murielle
Mbula Mambimbi, Marcel
Etienne, Mokondjimobe
Buassa-bu-Tsumbu, Baudouin
Gombet, Thierry
Ellenga, Bertrain
Milongo Dipa, Guy
Lukoki Luila, Evelyne
Nge Okwe, Augustin
author_sort Longo-Mbenza, Benjamin
collection PubMed
description INTRODUCTION: The metabolic syndrome (MetS) is common in human immune deficiency virus (HIV)-infected individuals receiving highly active antiretroviral therapy (HAART). Immune deficiencies caused by HIV give rise to numerous opportunistic gastrointestinal pathogens such as Helicobacter pylori, the commonest cause of chronic gastritis. The study sought to determine the relationship between H pylori infection and the MetS among HIV-infected clinic attendees. METHODS: This cross-sectional study was carried out in a specialised heart clinic in Kinshasa, DR Congo. Between January 2004 and December 2008, 116 HIV-infected patients (61 with MetS and 55 without MetS) who underwent upper gastrointestinal endoscopy for dyspeptic symptoms were included in the study following an informed consent. Univariate associations were determined by odds ratios (OR), while multivariate logistic regression analysis was used to identify factors associated with the MetS. RESULTS: H pylori infection (OR = 13.5, 95% CI: 10.3–17.6; p < 0.0001) and peripheral obesity (median hip circumference ≥ 97 cm) (OR = 4.7, 95% CI: 1.2–18.8; p = 0.029) were identified as MetS-related factors in HIV-infected patients. Higher rates of the MetS were associated with increased incidence of HIV-related immunocompromise using World Health Organisation (WHO) staging criteria. There was a univariate significant difference in the prevalence of the MetS between antiretroviral therapy (ART)-naïve patients and patients treated by means of a first-line HAART regimen of stavudine (d4T), lamivudine (3TC) and nevirapine (NVP). However, this difference was not significant in multivariate logistic analysis. CONCLUSION: H pylori infection was significantly associated with the MetS in HIV-infected patients.
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spelling pubmed-48155052016-04-20 Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy Longo-Mbenza, Benjamin Apalata, Teke Longokolo, Murielle Mbula Mambimbi, Marcel Etienne, Mokondjimobe Buassa-bu-Tsumbu, Baudouin Gombet, Thierry Ellenga, Bertrain Milongo Dipa, Guy Lukoki Luila, Evelyne Nge Okwe, Augustin Cardiovasc J Afr Cardiovascular Topics INTRODUCTION: The metabolic syndrome (MetS) is common in human immune deficiency virus (HIV)-infected individuals receiving highly active antiretroviral therapy (HAART). Immune deficiencies caused by HIV give rise to numerous opportunistic gastrointestinal pathogens such as Helicobacter pylori, the commonest cause of chronic gastritis. The study sought to determine the relationship between H pylori infection and the MetS among HIV-infected clinic attendees. METHODS: This cross-sectional study was carried out in a specialised heart clinic in Kinshasa, DR Congo. Between January 2004 and December 2008, 116 HIV-infected patients (61 with MetS and 55 without MetS) who underwent upper gastrointestinal endoscopy for dyspeptic symptoms were included in the study following an informed consent. Univariate associations were determined by odds ratios (OR), while multivariate logistic regression analysis was used to identify factors associated with the MetS. RESULTS: H pylori infection (OR = 13.5, 95% CI: 10.3–17.6; p < 0.0001) and peripheral obesity (median hip circumference ≥ 97 cm) (OR = 4.7, 95% CI: 1.2–18.8; p = 0.029) were identified as MetS-related factors in HIV-infected patients. Higher rates of the MetS were associated with increased incidence of HIV-related immunocompromise using World Health Organisation (WHO) staging criteria. There was a univariate significant difference in the prevalence of the MetS between antiretroviral therapy (ART)-naïve patients and patients treated by means of a first-line HAART regimen of stavudine (d4T), lamivudine (3TC) and nevirapine (NVP). However, this difference was not significant in multivariate logistic analysis. CONCLUSION: H pylori infection was significantly associated with the MetS in HIV-infected patients. Clinics Cardive Publishing 2015 /pmc/articles/PMC4815505/ /pubmed/25940117 http://dx.doi.org/10.5830/CVJA-2015-012 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Cardiovascular Topics
Longo-Mbenza, Benjamin
Apalata, Teke
Longokolo, Murielle
Mbula Mambimbi, Marcel
Etienne, Mokondjimobe
Buassa-bu-Tsumbu, Baudouin
Gombet, Thierry
Ellenga, Bertrain
Milongo Dipa, Guy
Lukoki Luila, Evelyne
Nge Okwe, Augustin
Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy
title Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy
title_full Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy
title_fullStr Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy
title_full_unstemmed Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy
title_short Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy
title_sort association of helicobacter pylori infection with the metabolic syndrome among hiv-infected black africans receiving highly active antiretroviral therapy
topic Cardiovascular Topics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815505/
https://www.ncbi.nlm.nih.gov/pubmed/25940117
http://dx.doi.org/10.5830/CVJA-2015-012
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