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Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy
INTRODUCTION: The metabolic syndrome (MetS) is common in human immune deficiency virus (HIV)-infected individuals receiving highly active antiretroviral therapy (HAART). Immune deficiencies caused by HIV give rise to numerous opportunistic gastrointestinal pathogens such as Helicobacter pylori, the...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Clinics Cardive Publishing
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815505/ https://www.ncbi.nlm.nih.gov/pubmed/25940117 http://dx.doi.org/10.5830/CVJA-2015-012 |
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author | Longo-Mbenza, Benjamin Apalata, Teke Longokolo, Murielle Mbula Mambimbi, Marcel Etienne, Mokondjimobe Buassa-bu-Tsumbu, Baudouin Gombet, Thierry Ellenga, Bertrain Milongo Dipa, Guy Lukoki Luila, Evelyne Nge Okwe, Augustin |
author_facet | Longo-Mbenza, Benjamin Apalata, Teke Longokolo, Murielle Mbula Mambimbi, Marcel Etienne, Mokondjimobe Buassa-bu-Tsumbu, Baudouin Gombet, Thierry Ellenga, Bertrain Milongo Dipa, Guy Lukoki Luila, Evelyne Nge Okwe, Augustin |
author_sort | Longo-Mbenza, Benjamin |
collection | PubMed |
description | INTRODUCTION: The metabolic syndrome (MetS) is common in human immune deficiency virus (HIV)-infected individuals receiving highly active antiretroviral therapy (HAART). Immune deficiencies caused by HIV give rise to numerous opportunistic gastrointestinal pathogens such as Helicobacter pylori, the commonest cause of chronic gastritis. The study sought to determine the relationship between H pylori infection and the MetS among HIV-infected clinic attendees. METHODS: This cross-sectional study was carried out in a specialised heart clinic in Kinshasa, DR Congo. Between January 2004 and December 2008, 116 HIV-infected patients (61 with MetS and 55 without MetS) who underwent upper gastrointestinal endoscopy for dyspeptic symptoms were included in the study following an informed consent. Univariate associations were determined by odds ratios (OR), while multivariate logistic regression analysis was used to identify factors associated with the MetS. RESULTS: H pylori infection (OR = 13.5, 95% CI: 10.3–17.6; p < 0.0001) and peripheral obesity (median hip circumference ≥ 97 cm) (OR = 4.7, 95% CI: 1.2–18.8; p = 0.029) were identified as MetS-related factors in HIV-infected patients. Higher rates of the MetS were associated with increased incidence of HIV-related immunocompromise using World Health Organisation (WHO) staging criteria. There was a univariate significant difference in the prevalence of the MetS between antiretroviral therapy (ART)-naïve patients and patients treated by means of a first-line HAART regimen of stavudine (d4T), lamivudine (3TC) and nevirapine (NVP). However, this difference was not significant in multivariate logistic analysis. CONCLUSION: H pylori infection was significantly associated with the MetS in HIV-infected patients. |
format | Online Article Text |
id | pubmed-4815505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Clinics Cardive Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-48155052016-04-20 Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy Longo-Mbenza, Benjamin Apalata, Teke Longokolo, Murielle Mbula Mambimbi, Marcel Etienne, Mokondjimobe Buassa-bu-Tsumbu, Baudouin Gombet, Thierry Ellenga, Bertrain Milongo Dipa, Guy Lukoki Luila, Evelyne Nge Okwe, Augustin Cardiovasc J Afr Cardiovascular Topics INTRODUCTION: The metabolic syndrome (MetS) is common in human immune deficiency virus (HIV)-infected individuals receiving highly active antiretroviral therapy (HAART). Immune deficiencies caused by HIV give rise to numerous opportunistic gastrointestinal pathogens such as Helicobacter pylori, the commonest cause of chronic gastritis. The study sought to determine the relationship between H pylori infection and the MetS among HIV-infected clinic attendees. METHODS: This cross-sectional study was carried out in a specialised heart clinic in Kinshasa, DR Congo. Between January 2004 and December 2008, 116 HIV-infected patients (61 with MetS and 55 without MetS) who underwent upper gastrointestinal endoscopy for dyspeptic symptoms were included in the study following an informed consent. Univariate associations were determined by odds ratios (OR), while multivariate logistic regression analysis was used to identify factors associated with the MetS. RESULTS: H pylori infection (OR = 13.5, 95% CI: 10.3–17.6; p < 0.0001) and peripheral obesity (median hip circumference ≥ 97 cm) (OR = 4.7, 95% CI: 1.2–18.8; p = 0.029) were identified as MetS-related factors in HIV-infected patients. Higher rates of the MetS were associated with increased incidence of HIV-related immunocompromise using World Health Organisation (WHO) staging criteria. There was a univariate significant difference in the prevalence of the MetS between antiretroviral therapy (ART)-naïve patients and patients treated by means of a first-line HAART regimen of stavudine (d4T), lamivudine (3TC) and nevirapine (NVP). However, this difference was not significant in multivariate logistic analysis. CONCLUSION: H pylori infection was significantly associated with the MetS in HIV-infected patients. Clinics Cardive Publishing 2015 /pmc/articles/PMC4815505/ /pubmed/25940117 http://dx.doi.org/10.5830/CVJA-2015-012 Text en Copyright © 2010 Clinics Cardive Publishing http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Cardiovascular Topics Longo-Mbenza, Benjamin Apalata, Teke Longokolo, Murielle Mbula Mambimbi, Marcel Etienne, Mokondjimobe Buassa-bu-Tsumbu, Baudouin Gombet, Thierry Ellenga, Bertrain Milongo Dipa, Guy Lukoki Luila, Evelyne Nge Okwe, Augustin Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy |
title | Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy |
title_full | Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy |
title_fullStr | Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy |
title_full_unstemmed | Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy |
title_short | Association of Helicobacter pylori infection with the metabolic syndrome among HIV-infected black Africans receiving highly active antiretroviral therapy |
title_sort | association of helicobacter pylori infection with the metabolic syndrome among hiv-infected black africans receiving highly active antiretroviral therapy |
topic | Cardiovascular Topics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815505/ https://www.ncbi.nlm.nih.gov/pubmed/25940117 http://dx.doi.org/10.5830/CVJA-2015-012 |
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