FGF23 as a calciotropic hormone

Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol – 1,25(OH) (2)D (3) – and induces phosphaturia. The consequences of a reduction in 1,25(OH) (2)D (3) involve c...

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Detalles Bibliográficos
Autores principales: Rodríguez-Ortiz, María E., Rodríguez, Mariano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815615/
https://www.ncbi.nlm.nih.gov/pubmed/27081473
http://dx.doi.org/10.12688/f1000research.7189.1
Descripción
Sumario:Maintaining mineral metabolism requires several organs and hormones. Fibroblast growth factor 23 (FGF23) is a phosphatonin produced by bone cells that reduces renal production of calcitriol – 1,25(OH) (2)D (3) – and induces phosphaturia. The consequences of a reduction in 1,25(OH) (2)D (3) involve changes in calcium homeostasis. There are several factors that regulate FGF23: phosphorus, vitamin D, and parathyroid hormone (PTH). More recently, several studies have demonstrated that calcium also modulates FGF23 production. In a situation of calcium deficiency, the presence of 1,25(OH) (2)D (3) is necessary to optimize intestinal absorption of calcium, and FGF23 is decreased to avoid a reduction in 1,25(OH) (2)D (3) levels.

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