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Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum

BACKGROUND: Low-grade serous carcinoma of the ovary or peritoneum is a distinct, well- recognized histologic subtype characterized by young age at diagnosis, relative chemoresistance, and prolonged overall survival. Common mutations reported to be found within this subtype include KRAS and BRAF. MET...

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Autores principales: Gershenson, David M, Sun, Charlotte C, Wong, Kwong-Kwok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815788/
https://www.ncbi.nlm.nih.gov/pubmed/26484411
http://dx.doi.org/10.1038/bjc.2015.364
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author Gershenson, David M
Sun, Charlotte C
Wong, Kwong-Kwok
author_facet Gershenson, David M
Sun, Charlotte C
Wong, Kwong-Kwok
author_sort Gershenson, David M
collection PubMed
description BACKGROUND: Low-grade serous carcinoma of the ovary or peritoneum is a distinct, well- recognized histologic subtype characterized by young age at diagnosis, relative chemoresistance, and prolonged overall survival. Common mutations reported to be found within this subtype include KRAS and BRAF. METHODS: Using clinical information of patients from our IRB-approved registry and tissue from a subset of these patients, we performed mutational analysis for KRAS and BRAF using the direct Sanger sequencing technique and correlated findings with the clinical outcome, overall survival (OS). RESULTS: In 79 cases, patients with KRAS or BRAF mutations (n=21) had a significantly better OS than those with wild-type KRAS or BRAF (n=58) (106.7 months (95% CI, 50.6, 162.9) vs 66.8 months (95% CI, 43.6, 90.0)), respectively (P=0.018). CONCLUSIONS: Mutational status appears to be a potential prognostic factor in low-grade serous carcinoma of the ovary or peritoneum.
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spelling pubmed-48157882016-11-03 Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum Gershenson, David M Sun, Charlotte C Wong, Kwong-Kwok Br J Cancer Short Communication BACKGROUND: Low-grade serous carcinoma of the ovary or peritoneum is a distinct, well- recognized histologic subtype characterized by young age at diagnosis, relative chemoresistance, and prolonged overall survival. Common mutations reported to be found within this subtype include KRAS and BRAF. METHODS: Using clinical information of patients from our IRB-approved registry and tissue from a subset of these patients, we performed mutational analysis for KRAS and BRAF using the direct Sanger sequencing technique and correlated findings with the clinical outcome, overall survival (OS). RESULTS: In 79 cases, patients with KRAS or BRAF mutations (n=21) had a significantly better OS than those with wild-type KRAS or BRAF (n=58) (106.7 months (95% CI, 50.6, 162.9) vs 66.8 months (95% CI, 43.6, 90.0)), respectively (P=0.018). CONCLUSIONS: Mutational status appears to be a potential prognostic factor in low-grade serous carcinoma of the ovary or peritoneum. Nature Publishing Group 2015-11-03 2015-10-20 /pmc/articles/PMC4815788/ /pubmed/26484411 http://dx.doi.org/10.1038/bjc.2015.364 Text en Copyright © 2015 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Short Communication
Gershenson, David M
Sun, Charlotte C
Wong, Kwong-Kwok
Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum
title Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum
title_full Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum
title_fullStr Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum
title_full_unstemmed Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum
title_short Impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum
title_sort impact of mutational status on survival in low-grade serous carcinoma of the ovary or peritoneum
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815788/
https://www.ncbi.nlm.nih.gov/pubmed/26484411
http://dx.doi.org/10.1038/bjc.2015.364
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