A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours

BACKGROUND: The current biomarkers alpha-fetoprotein and human chorionic gonadotropin have limited sensitivity and specificity for diagnosing malignant germ-cell tumours (GCTs). MicroRNAs (miRNAs) from the miR–371–373 and miR–302/367 clusters are overexpressed in all malignant GCTs, and some of thes...

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Detalles Bibliográficos
Autores principales: Murray, Matthew J, Bell, Emma, Raby, Katie L, Rijlaarsdam, Martin A, Gillis, Ad J M, Looijenga, Leendert H J, Brown, Helen, Destenaves, Benoit, Nicholson, James C, Coleman, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815809/
https://www.ncbi.nlm.nih.gov/pubmed/26671749
http://dx.doi.org/10.1038/bjc.2015.429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815809/
https://www.ncbi.nlm.nih.gov/pubmed/26671749
http://dx.doi.org/10.1038/bjc.2015.429

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