Cargando…

A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours

BACKGROUND: The current biomarkers alpha-fetoprotein and human chorionic gonadotropin have limited sensitivity and specificity for diagnosing malignant germ-cell tumours (GCTs). MicroRNAs (miRNAs) from the miR–371–373 and miR–302/367 clusters are overexpressed in all malignant GCTs, and some of thes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Murray, Matthew J, Bell, Emma, Raby, Katie L, Rijlaarsdam, Martin A, Gillis, Ad J M, Looijenga, Leendert H J, Brown, Helen, Destenaves, Benoit, Nicholson, James C, Coleman, Nicholas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815809/ https://www.ncbi.nlm.nih.gov/pubmed/26671749 http://dx.doi.org/10.1038/bjc.2015.429

Ejemplares similares

Prediction of relapse in stage I testicular germ cell tumor patients on surveillance: investigation of biomarkers
por: Lobo, João, et al.
Publicado: (2020)

Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors
por: Rijlaarsdam, Martin A., et al.
Publicado: (2015)

Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic
por: Lobo, João, et al.
Publicado: (2019)

DICER1 RNase IIIb domain mutations are infrequent in testicular germ cell tumours
por: de Boer, Carmela M, et al.
Publicado: (2012)

VASA mRNA (DDX4) detection is more specific than immunohistochemistry using poly- or monoclonal antibodies for germ cells in the male urogenital tract
por: Boellaard, Willem P.A., et al.
Publicado: (2017)

Seminoma and Embryonal Carcinoma Footprints Identified by Analysis of Integrated Genome-Wide Epigenetic and Expression Profiles of Germ Cell Cancer Cell Lines
por: van der Zwan, Yvonne G., et al.
Publicado: (2014)

CRIPTO and miR-371a-3p Are Serum Biomarkers of Testicular Germ Cell Tumors and Are Detected in Seminal Plasma from Azoospermic Males
por: Spiller, Cassy M., et al.
Publicado: (2020)

The Role of TP53 in Cisplatin Resistance in Mediastinal and Testicular Germ Cell Tumors
por: Timmerman, Dennis M., et al.
Publicado: (2021)

Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors
por: Eckert, Dawid, et al.
Publicado: (2008)

Analysis of a mouse germ cell tumor model establishes pluripotency-associated miRNAs as conserved serum biomarkers for germ cell cancer detection
por: Loehr, Amanda R., et al.
Publicado: (2023)

XIST-Promoter Demethylation as Tissue Biomarker for Testicular Germ Cell Tumors and Spermatogenesis Quality
por: Lobo, João, et al.
Publicado: (2019)

Comparative Analyses of Liquid-Biopsy MicroRNA371a-3p Isolation Protocols for Serum and Plasma
por: Timmerman, Dennis M., et al.
Publicado: (2021)

Accurate primary germ cell cancer diagnosis using serum based microRNA detection (ampTSmiR test)
por: van Agthoven, Ton, et al.
Publicado: (2016)

Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development
por: Dorssers, Lambert C. J., et al.
Publicado: (2019)

Predicting Gonadal Germ Cell Cancer in People with Disorders of Sex Development; Insights from Developmental Biology
por: Looijenga, Leendert H. J., et al.
Publicado: (2019)

Treatment and Survival of Malignant Extracranial Germ Cell Tumours in the Paediatric Population: A Systematic Review and Meta-Analysis
por: Hulsker, Caroline C. C., et al.
Publicado: (2021)

Combining Hypermethylated RASSF1A Detection Using ddPCR with miR-371a-3p Testing: An Improved Panel of Liquid Biopsy Biomarkers for Testicular Germ Cell Tumor Patients
por: Lobo, João, et al.
Publicado: (2021)

Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours
por: Rijlaarsdam, M A, et al.
Publicado: (2011)

Specific detection of OCT3/4 isoform A/B/B1 expression in solid (germ cell) tumours and cell lines: confirmation of OCT3/4 specificity for germ cell tumours
por: Rijlaarsdam, M A, et al.
Publicado: (2012)

Screening for cancers with a good prognosis: The case of testicular germ cell cancer
por: Heijnsdijk, Eveline A. M., et al.
Publicado: (2021)

Napabucasin overcomes cisplatin resistance in ovarian germ cell tumor-derived cell line by inhibiting cancer stemness
por: Schmidtova, Silvia, et al.
Publicado: (2020)

Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis
por: Timmerman, Dennis M., et al.
Publicado: (2021)

microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients
por: van Agthoven, Ton, et al.
Publicado: (2017)

Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis
por: Elzinga-Tinke, Jenny E, et al.
Publicado: (2015)

Expression of Intermediate Filaments in the Developing Testis and Testicular Germ Cell Cancer
por: Camacho-Moll, Maria E., et al.
Publicado: (2022)

Chromosome 3p25.3 Gain Is Associated With Cisplatin Resistance and Is an Independent Predictor of Poor Outcome in Male Malignant Germ Cell Tumors
por: Timmerman, Dennis M., et al.
Publicado: (2022)

DMRforPairs: identifying Differentially Methylated Regions between unique samples using array based methylation profiles
por: Rijlaarsdam, Martin A, et al.
Publicado: (2014)

Role of SOX2 in the Etiology of Embryonal Carcinoma, Based on Analysis of the NCCIT and NT2 Cell Lines
por: Eini, Ronak, et al.
Publicado: (2014)

Recurrence of a Mediastinal Germ-Cell Tumor as a Somatic-Type Malignancy: A Complex Case Report
por: Hulsker, Caroline C. C., et al.
Publicado: (2021)

Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors
por: Killian, J. Keith, et al.
Publicado: (2016)

Clinical utility of plasma miR‐371a‐3p in germ cell tumors
por: Mego, Michal, et al.
Publicado: (2018)

Humanised Mice and Immunodeficient Mice (NSG) Are Equally Sensitive for Prediction of Stem Cell Malignancy in the Teratoma Assay
por: Bialecka, Monika, et al.
Publicado: (2022)

Identification and Validation Model for Informative Liquid Biopsy-Based microRNA Biomarkers: Insights from Germ Cell Tumor In Vitro, In Vivo and Patient-Derived Data
por: Lobo, João, et al.
Publicado: (2019)

Paclitaxel, Ifosfamide, and Cisplatin in Patients with Poor-prognosis Disseminated Nonseminomatous Germ Cell Tumors with Unfavorable Serum Tumor Marker Decline After First Cycle of Chemotherapy. The GCT-SK-003 Phase II Trial
por: Mego, Michal, et al.
Publicado: (2021)

Delayed Recognition of Disorders of Sex Development (DSD): A Missed Opportunity for Early Diagnosis of Malignant Germ Cell Tumors
por: Hersmus, Remko, et al.
Publicado: (2012)

Biology of childhood germ cell tumours, focussing on the significance of microRNAs
por: Murray, M J, et al.
Publicado: (2015)

Integrated genomic analysis reveals aberrations in WNT signaling in germ cell tumors of childhood and adolescence
por: Xu, Lin, et al.
Publicado: (2023)

c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors
por: Scheri, Katia Corano, et al.
Publicado: (2018)

Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest
por: Lobo, João, et al.
Publicado: (2021)

Correction: c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors
por: Scheri, Katia Corano, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_domf4a5dq8kok7hsnilrhsipbt