Cargando…

Polygenic susceptibility to testicular cancer: implications for personalised health care

Mostrar otras versiones (1)

BACKGROUND: The increasing incidence of testicular germ cell tumour (TGCT) combined with its strong heritable basis suggests that stratified screening for the early detection of TGCT may be clinically useful. We modelled the efficiency of such a personalised screening approach, based on genetic risk...

Descripción completa

Detalles Bibliográficos
Autores principales:	Litchfield, Kevin, Mitchell, Jonathan S, Shipley, Janet, Huddart, Robert, Rajpert-De Meyts, Ewa, Skakkebæk, Niels E, Houlston, Richard S, Turnbull, Clare
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Genetics & Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815881/ https://www.ncbi.nlm.nih.gov/pubmed/26461055 http://dx.doi.org/10.1038/bjc.2015.334

Ejemplares similares

Polygenic susceptibility to testicular cancer: implications for personalised health care
por: Litchfield, Kevin, et al.
Publicado: (2016)

Polygenic susceptibility to prostate and breast cancer: implications for personalised screening
por: Pashayan, N, et al.
Publicado: (2011)

Genome-wide gene expression profiling of testicular carcinoma in situ progression into overt tumours
por: Almstrup, K, et al.
Publicado: (2005)

Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells
por: Almstrup, K, et al.
Publicado: (2010)

Identification of four new susceptibility loci for testicular germ cell tumour
por: Litchfield, Kevin, et al.
Publicado: (2015)

Rare disruptive mutations in ciliary function genes contribute to testicular cancer susceptibility
por: Litchfield, Kevin, et al.
Publicado: (2016)

Polygenic risk scores: An overview from bench to bedside for personalised medicine
por: Cross, Benjamin, et al.
Publicado: (2022)

Whole-exome sequencing reveals the mutational spectrum of testicular germ cell tumours
por: Litchfield, Kevin, et al.
Publicado: (2015)

A physical analysis of the Y chromosome shows no additional deletions, other than Gr/Gr, associated with testicular germ cell tumour
por: Linger, R, et al.
Publicado: (2007)

Can education be personalised using pupils’ genetic data?
por: Morris, Tim T, et al.
Publicado: (2020)

Quantifying the heritability of testicular germ cell tumour using both population-based and genomic approaches
por: Litchfield, Kevin, et al.
Publicado: (2015)

CHEK2 variants in susceptibility to breast cancer and evidence of retention of the wild type allele in tumours
por: Sodha, N, et al.
Publicado: (2002)

Nomograms of human hippocampal volume shifted by polygenic scores
por: Janahi, Mohammed, et al.
Publicado: (2022)

Somatic mutations of KIT in familial testicular germ cell tumours
por: Rapley, E A, et al.
Publicado: (2004)

Increased prevalence of testicular microlithiasis in men with familial testicular cancer and their relatives
por: Korde, L A, et al.
Publicado: (2008)

Will polygenic risk scores for cancer ever be clinically useful?
por: Sud, Amit, et al.
Publicado: (2021)

Personalised medicine in Canada: a survey of adoption and practice in oncology, cardiology and family medicine
por: Bonter, Katherine, et al.
Publicado: (2011)

A personalised approach to prostate cancer screening based on genotyping of risk founder alleles
por: Cybulski, C, et al.
Publicado: (2013)

Variable prediction accuracy of polygenic scores within an ancestry group
por: Mostafavi, Hakhamanesh, et al.
Publicado: (2020)

Utility of polygenic embryo screening for disease depends on the selection strategy
por: Lencz, Todd, et al.
Publicado: (2021)

Search for inherited susceptibility to radiation-associated meningioma by genomewide SNP linkage disequilibrium mapping
por: Hosking, F J, et al.
Publicado: (2011)

Relationship between rice farming and polygenic scores potentially linked to agriculture in China
por: Zhu, Chen, et al.
Publicado: (2021)

Low frequency of somatic mutations in the FH/multiple cutaneous leiomyomatosis gene in sporadic leiomyosarcomas and uterine leiomyomas
por: Barker, K T, et al.
Publicado: (2002)

Hypermethylation of genes in testicular embryonal carcinomas
por: Cheung, Hoi-Hung, et al.
Publicado: (2016)

Genome-Wide Assessment of the Association of Rare and Common Copy Number Variations to Testicular Germ Cell Cancer
por: Edsgärd, Daniel, et al.
Publicado: (2013)

An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
por: Richardson, Tom G, et al.
Publicado: (2019)

GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
por: Sinnott-Armstrong, Nasa, et al.
Publicado: (2021)

Associations of Filaggrin Gene Loss-of-Function Variants with Urinary Phthalate Metabolites and Testicular Function in Young Danish Men
por: Joensen, Ulla Nordström, et al.
Publicado: (2014)

Molecular Characteristics of Malignant Ovarian Germ Cell Tumors and Comparison With Testicular Counterparts: Implications for Pathogenesis
por: Kraggerud, Sigrid Marie, et al.
Publicado: (2013)

Genomic landscape of platinum resistant and sensitive testicular cancers
por: Loveday, Chey, et al.
Publicado: (2020)

Luteinizing Hormone Receptor Is Expressed in Testicular Germ Cell Tumors: Possible Implications for Tumor Growth and Prognosis
por: Lorenzen, Mette, et al.
Publicado: (2020)

Evaluation of Circulating miRNA Biomarkers of Testicular Germ Cell Tumors during Therapy and Follow-up―A Copenhagen Experience
por: Mørup, Nina, et al.
Publicado: (2020)

Criminality in men with Klinefelter's syndrome and XYY syndrome: a cohort study
por: Stochholm, Kirstine, et al.
Publicado: (2012)

BRCA1 testing should be offered to individuals with triple-negative breast cancer diagnosed below 50 years
por: Robertson, L, et al.
Publicado: (2012)

Low penetrance susceptibility to glioma is caused by the TP53 variant rs78378222
por: Enciso-Mora, V, et al.
Publicado: (2013)

Optimized detection of germ cell neoplasia in situ in contralateral biopsy reduces the risk of second testis cancer
por: Rajpert‐De Meyts, Ewa, et al.
Publicado: (2022)

Realistic expectations are key to realising the benefits of polygenic scores
por: Sud, Amit, et al.
Publicado: (2023)

Microarray comparative genomic hybridisation analysis of intraocular uveal melanomas identifies distinctive imbalances associated with loss of chromosome 3
por: Hughes, S, et al.
Publicado: (2005)

Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14
por: Ruark, Elise, et al.
Publicado: (2013)

Genome-wide DNA methylation profiling reveals novel epigenetically regulated genes and non-coding RNAs in human testicular cancer
por: Cheung, H H, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_dvhqh7914i0lvmh0b1ns8frm86