HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism

Upon severe DNA damage a cellular signalling network initiates a cell death response through activating tumour suppressor p53 in association with promyelocytic leukaemia (PML) nuclear bodies. The deacetylase Sirtuin 1 (SIRT1) suppresses cell death after DNA damage by antagonizing p53 acetylation. To...

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Detalles Bibliográficos
Autores principales: Conrad, E, Polonio-Vallon, T, Meister, M, Matt, S, Bitomsky, N, Herbel, C, Liebl, M, Greiner, V, Kriznik, B, Schumacher, S, Krieghoff-Henning, E, Hofmann, T G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4815982/
https://www.ncbi.nlm.nih.gov/pubmed/26113041
http://dx.doi.org/10.1038/cdd.2015.75

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