Mesenchymal stem cells and immunomodulation: current status and future prospects

The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host dis...

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Autores principales: Gao, F, Chiu, S M, Motan, D A L, Zhang, Z, Chen, L, Ji, H-L, Tse, H-F, Fu, Q-L, Lian, Q
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816164/
https://www.ncbi.nlm.nih.gov/pubmed/26794657
http://dx.doi.org/10.1038/cddis.2015.327
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author Gao, F
Chiu, S M
Motan, D A L
Zhang, Z
Chen, L
Ji, H-L
Tse, H-F
Fu, Q-L
Lian, Q
author_facet Gao, F
Chiu, S M
Motan, D A L
Zhang, Z
Chen, L
Ji, H-L
Tse, H-F
Fu, Q-L
Lian, Q
author_sort Gao, F
collection PubMed
description The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC-based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the future development of pluripotent stem cell-derived MSCs as an approach to immunomodulation therapy.
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spelling pubmed-48161642016-04-13 Mesenchymal stem cells and immunomodulation: current status and future prospects Gao, F Chiu, S M Motan, D A L Zhang, Z Chen, L Ji, H-L Tse, H-F Fu, Q-L Lian, Q Cell Death Dis Review The unique immunomodulatory properties of mesenchymal stem cells (MSCs) make them an invaluable cell type for the repair of tissue/ organ damage caused by chronic inflammation or autoimmune disorders. Although they hold great promise in the treatment of immune disorders such as graft versus host disease (GvHD) and allergic disorders, there remain many challenges to overcome before their widespread clinical application. An understanding of the biological properties of MSCs will clarify the mechanisms of MSC-based transplantation for immunomodulation. In this review, we summarize the preclinical and clinical studies of MSCs from different adult tissues, discuss the current hurdles to their use and propose the future development of pluripotent stem cell-derived MSCs as an approach to immunomodulation therapy. Nature Publishing Group 2016-01 2016-01-21 /pmc/articles/PMC4816164/ /pubmed/26794657 http://dx.doi.org/10.1038/cddis.2015.327 Text en Copyright © 2016 Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Review
Gao, F
Chiu, S M
Motan, D A L
Zhang, Z
Chen, L
Ji, H-L
Tse, H-F
Fu, Q-L
Lian, Q
Mesenchymal stem cells and immunomodulation: current status and future prospects
title Mesenchymal stem cells and immunomodulation: current status and future prospects
title_full Mesenchymal stem cells and immunomodulation: current status and future prospects
title_fullStr Mesenchymal stem cells and immunomodulation: current status and future prospects
title_full_unstemmed Mesenchymal stem cells and immunomodulation: current status and future prospects
title_short Mesenchymal stem cells and immunomodulation: current status and future prospects
title_sort mesenchymal stem cells and immunomodulation: current status and future prospects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816164/
https://www.ncbi.nlm.nih.gov/pubmed/26794657
http://dx.doi.org/10.1038/cddis.2015.327
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