Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia

SMAC-mimetics represent a targeted therapy approach to overcome apoptosis resistance in many tumors. Here, we investigated the efficacy of the SMAC-mimetic BV6 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In ALL cell lines, intrinsic apoptosis sensitivity was associated with rapid cIA...

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Detalles Bibliográficos
Autores principales: Schirmer, M, Trentin, L, Queudeville, M, Seyfried, F, Demir, S, Tausch, E, Stilgenbauer, S, Eckhoff, S M, Meyer, L H, Debatin, K-M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816168/
https://www.ncbi.nlm.nih.gov/pubmed/26775704
http://dx.doi.org/10.1038/cddis.2015.382

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