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Systematic Review of Pancreatic Cyst Fluid Biomarkers: The Path Forward

There is significant research interest in developing and validating novel pancreatic cyst-fluid biomarkers given the increasing recognition of the prevalence of pancreatic cysts and their associated malignant potential. Although current international consensus guidelines are helpful, they fail to di...

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Autores principales: Thiruvengadam, Nikhil, Park, Walter G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816245/
https://www.ncbi.nlm.nih.gov/pubmed/26065716
http://dx.doi.org/10.1038/ctg.2015.17
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author Thiruvengadam, Nikhil
Park, Walter G
author_facet Thiruvengadam, Nikhil
Park, Walter G
author_sort Thiruvengadam, Nikhil
collection PubMed
description There is significant research interest in developing and validating novel pancreatic cyst-fluid biomarkers given the increasing recognition of the prevalence of pancreatic cysts and their associated malignant potential. Although current international consensus guidelines are helpful, they fail to diagnose with certainty the cyst type and the level of epithelial dysplasia. They also fall short in predicting the future likelihood of malignant transformation. A systematic review was performed with the objective of summarizing cyst-fluid-based biomarkers that have been published in the medical literature over the past 10 years and characterizing the current quality of evidence. Our review demonstrates that there is an increasing interest in this topic with several different and innovative approaches including DNA, RNA, proteomic, and metabolomics profiling. Further techniques to improve upon cytological yield have also been studied. Besides identifying potentially useful clinical biomarkers, these empiric approaches have provided further insight into their pathogenesis. The level of evidence for the vast majority of these studies, however, is limited to retrospective early validation studies. The path forward will be to select out the most promising biomarkers and develop multicenter consortiums capable of capturing adequate sample sizes with appropriate study designs.
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spelling pubmed-48162452016-04-13 Systematic Review of Pancreatic Cyst Fluid Biomarkers: The Path Forward Thiruvengadam, Nikhil Park, Walter G Clin Transl Gastroenterol Clinical/Narrative Review There is significant research interest in developing and validating novel pancreatic cyst-fluid biomarkers given the increasing recognition of the prevalence of pancreatic cysts and their associated malignant potential. Although current international consensus guidelines are helpful, they fail to diagnose with certainty the cyst type and the level of epithelial dysplasia. They also fall short in predicting the future likelihood of malignant transformation. A systematic review was performed with the objective of summarizing cyst-fluid-based biomarkers that have been published in the medical literature over the past 10 years and characterizing the current quality of evidence. Our review demonstrates that there is an increasing interest in this topic with several different and innovative approaches including DNA, RNA, proteomic, and metabolomics profiling. Further techniques to improve upon cytological yield have also been studied. Besides identifying potentially useful clinical biomarkers, these empiric approaches have provided further insight into their pathogenesis. The level of evidence for the vast majority of these studies, however, is limited to retrospective early validation studies. The path forward will be to select out the most promising biomarkers and develop multicenter consortiums capable of capturing adequate sample sizes with appropriate study designs. Nature Publishing Group 2015-06 2015-06-11 /pmc/articles/PMC4816245/ /pubmed/26065716 http://dx.doi.org/10.1038/ctg.2015.17 Text en Copyright © 2015 American College of Gastroenterology http://creativecommons.org/licenses/by-nc-nd/4.0/ Clinical and Translational Gastroenterology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Clinical/Narrative Review
Thiruvengadam, Nikhil
Park, Walter G
Systematic Review of Pancreatic Cyst Fluid Biomarkers: The Path Forward
title Systematic Review of Pancreatic Cyst Fluid Biomarkers: The Path Forward
title_full Systematic Review of Pancreatic Cyst Fluid Biomarkers: The Path Forward
title_fullStr Systematic Review of Pancreatic Cyst Fluid Biomarkers: The Path Forward
title_full_unstemmed Systematic Review of Pancreatic Cyst Fluid Biomarkers: The Path Forward
title_short Systematic Review of Pancreatic Cyst Fluid Biomarkers: The Path Forward
title_sort systematic review of pancreatic cyst fluid biomarkers: the path forward
topic Clinical/Narrative Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816245/
https://www.ncbi.nlm.nih.gov/pubmed/26065716
http://dx.doi.org/10.1038/ctg.2015.17
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