Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects

OBJECTIVES: To evaluate safety, tolerability, pharmacokinetics, and pharmacodynamics of TAK-438 (vonoprazan, a potassium-competitive acid blocker) in healthy male subjects. METHODS: In two phase I, randomized, double-blind, placebo-controlled, single rising-dose studies, healthy male subjects (Japan...

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Detalles Bibliográficos
Autores principales: Sakurai, Yuuichi, Nishimura, Akira, Kennedy, Gale, Hibberd, Mark, Jenkins, Richard, Okamoto, Hiroyuki, Yoneyama, Tomoki, Jenkins, Helen, Ashida, Kiyoshi, Irie, Shin, Täubel, Jörg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Contributions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816246/
https://www.ncbi.nlm.nih.gov/pubmed/26111126
http://dx.doi.org/10.1038/ctg.2015.18

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