Cargando…

HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis

BACKGROUND: worldwide, hepatitis C and B virus infections (HCV and HCV), are the two most common coinfections with human immunodeficiency virus (HIV) and has become a major threat to the survival of HIV-infected persons. The review aimed to estimate the prevalence of HIV, HBV, HCV, HIV/HCV and HIV/H...

Descripción completa

Detalles Bibliográficos
Autores principales: Bagheri Amiri, Fahimeh, Mostafavi, Ehsan, Mirzazadeh, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816272/
https://www.ncbi.nlm.nih.gov/pubmed/27031352
http://dx.doi.org/10.1371/journal.pone.0151946
_version_ 1782424682105929728
author Bagheri Amiri, Fahimeh
Mostafavi, Ehsan
Mirzazadeh, Ali
author_facet Bagheri Amiri, Fahimeh
Mostafavi, Ehsan
Mirzazadeh, Ali
author_sort Bagheri Amiri, Fahimeh
collection PubMed
description BACKGROUND: worldwide, hepatitis C and B virus infections (HCV and HCV), are the two most common coinfections with human immunodeficiency virus (HIV) and has become a major threat to the survival of HIV-infected persons. The review aimed to estimate the prevalence of HIV, HBV, HCV, HIV/HCV and HIV/HBV and triple coinfections in different subpopulations in Iran. METHOD: Following PRISMA guidelines, we conducted a systematic review and meta-analysis of reports on prevalence of HIV, HBV, HCV and HIV coinfections in different subpopulations in Iran. We systematically reviewed the literature to identify eligible studies from January 1996 to March 2012 in English or Persian/Farsi databases. We extracted the prevalence of HIV antibodies (diagnosed by Elisa confirmed with Western Blot test), HCV antibodies and HBsAg (with confirmatory laboratory test) as the main primary outcome. We reported the prevalence of the three infections and coinfections as point and 95% confidence intervals. FINDINGS: HIV prevalence varied from %0.00 (95% CI: 0.00–0.003) in the general population to %17.25 (95% CI: 2.94–31.57) in people who inject drugs (PWID). HBV prevalence ranged from % 0.00 (95% CI: 0.00–7.87) in health care workers to % 30.9 (95% CI: 27.88–33.92) in PWID. HCV prevalence ranged from %0.19 (95% CI: 0.00–0.66) in health care workers to %51.46 (95% CI: 34.30–68.62) in PWID. The coinfection of HIV/HBV and also HIV/HCV in the general population and in health care workers was zero, while the most common coinfections were HIV/HCV (10.95%), HIV/HBV (1.88%) and triple infections (1.25%) in PWID. CONCLUSIONS: We found that PWID are severely and disproportionately affected by HIV and the other two infections, HCV and HBV. Screenings of such coinfections need to be reinforced to prevent new infections and also reduce further transmission in their community and to others.
format Online
Article
Text
id pubmed-4816272
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-48162722016-04-14 HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis Bagheri Amiri, Fahimeh Mostafavi, Ehsan Mirzazadeh, Ali PLoS One Research Article BACKGROUND: worldwide, hepatitis C and B virus infections (HCV and HCV), are the two most common coinfections with human immunodeficiency virus (HIV) and has become a major threat to the survival of HIV-infected persons. The review aimed to estimate the prevalence of HIV, HBV, HCV, HIV/HCV and HIV/HBV and triple coinfections in different subpopulations in Iran. METHOD: Following PRISMA guidelines, we conducted a systematic review and meta-analysis of reports on prevalence of HIV, HBV, HCV and HIV coinfections in different subpopulations in Iran. We systematically reviewed the literature to identify eligible studies from January 1996 to March 2012 in English or Persian/Farsi databases. We extracted the prevalence of HIV antibodies (diagnosed by Elisa confirmed with Western Blot test), HCV antibodies and HBsAg (with confirmatory laboratory test) as the main primary outcome. We reported the prevalence of the three infections and coinfections as point and 95% confidence intervals. FINDINGS: HIV prevalence varied from %0.00 (95% CI: 0.00–0.003) in the general population to %17.25 (95% CI: 2.94–31.57) in people who inject drugs (PWID). HBV prevalence ranged from % 0.00 (95% CI: 0.00–7.87) in health care workers to % 30.9 (95% CI: 27.88–33.92) in PWID. HCV prevalence ranged from %0.19 (95% CI: 0.00–0.66) in health care workers to %51.46 (95% CI: 34.30–68.62) in PWID. The coinfection of HIV/HBV and also HIV/HCV in the general population and in health care workers was zero, while the most common coinfections were HIV/HCV (10.95%), HIV/HBV (1.88%) and triple infections (1.25%) in PWID. CONCLUSIONS: We found that PWID are severely and disproportionately affected by HIV and the other two infections, HCV and HBV. Screenings of such coinfections need to be reinforced to prevent new infections and also reduce further transmission in their community and to others. Public Library of Science 2016-03-31 /pmc/articles/PMC4816272/ /pubmed/27031352 http://dx.doi.org/10.1371/journal.pone.0151946 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Bagheri Amiri, Fahimeh
Mostafavi, Ehsan
Mirzazadeh, Ali
HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis
title HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis
title_full HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis
title_fullStr HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis
title_full_unstemmed HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis
title_short HIV, HBV and HCV Coinfection Prevalence in Iran - A Systematic Review and Meta-Analysis
title_sort hiv, hbv and hcv coinfection prevalence in iran - a systematic review and meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816272/
https://www.ncbi.nlm.nih.gov/pubmed/27031352
http://dx.doi.org/10.1371/journal.pone.0151946
work_keys_str_mv AT bagheriamirifahimeh hivhbvandhcvcoinfectionprevalenceiniranasystematicreviewandmetaanalysis
AT mostafaviehsan hivhbvandhcvcoinfectionprevalenceiniranasystematicreviewandmetaanalysis
AT mirzazadehali hivhbvandhcvcoinfectionprevalenceiniranasystematicreviewandmetaanalysis