The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum

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Gastroesophageal reflux disease (GERD) is a highly prevalent chronic condition where in stomach contents reflux into the esophagus causing symptoms, esophageal injury, and subsequent complications. Proton pump inhibitors (PPI) remain the mainstay of therapy for acid suppression. Despite their effica...

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Autores principales: Hussain, Zilla H, Henderson, Emily E, Maradey-Romerao, Carla, George, Nina, Fass, Ronnie, Lacy, Brian E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Clinical/Narrative Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816276/
https://www.ncbi.nlm.nih.gov/pubmed/26270485
http://dx.doi.org/10.1038/ctg.2015.32
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author Hussain, Zilla H
Henderson, Emily E
Maradey-Romerao, Carla
George, Nina
Fass, Ronnie
Lacy, Brian E
author_facet Hussain, Zilla H
Henderson, Emily E
Maradey-Romerao, Carla
George, Nina
Fass, Ronnie
Lacy, Brian E
author_sort Hussain, Zilla H
collection PubMed
description Gastroesophageal reflux disease (GERD) is a highly prevalent chronic condition where in stomach contents reflux into the esophagus causing symptoms, esophageal injury, and subsequent complications. Proton pump inhibitors (PPI) remain the mainstay of therapy for acid suppression. Despite their efficacy, significant proportions of GERD patients are either partial or non-responders to PPI therapy. Patients should be assessed for mechanisms that can lead to PPI failure and may require further evaluation to investigate for alternative causes. This monograph will outline a diagnostic approach to the PPI non-responder, review mechanisms associated with PPI failure, and discuss therapeutic options for those who fail to respond to PPI therapy.
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spelling pubmed-48162762016-04-13 The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum Hussain, Zilla H Henderson, Emily E Maradey-Romerao, Carla George, Nina Fass, Ronnie Lacy, Brian E Clin Transl Gastroenterol Clinical/Narrative Review Gastroesophageal reflux disease (GERD) is a highly prevalent chronic condition where in stomach contents reflux into the esophagus causing symptoms, esophageal injury, and subsequent complications. Proton pump inhibitors (PPI) remain the mainstay of therapy for acid suppression. Despite their efficacy, significant proportions of GERD patients are either partial or non-responders to PPI therapy. Patients should be assessed for mechanisms that can lead to PPI failure and may require further evaluation to investigate for alternative causes. This monograph will outline a diagnostic approach to the PPI non-responder, review mechanisms associated with PPI failure, and discuss therapeutic options for those who fail to respond to PPI therapy. Nature Publishing Group 2015-08 2015-08-13 /pmc/articles/PMC4816276/ /pubmed/26270485 http://dx.doi.org/10.1038/ctg.2015.32 Text en Copyright © 2015 American College of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/4.0/ Clinical and Translational Gastroenterology is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
spellingShingle Clinical/Narrative Review
Hussain, Zilla H
Henderson, Emily E
Maradey-Romerao, Carla
George, Nina
Fass, Ronnie
Lacy, Brian E
The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum
title The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum
title_full The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum
title_fullStr The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum
title_full_unstemmed The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum
title_short The Proton Pump Inhibitor Non-Responder: A Clinical Conundrum
title_sort proton pump inhibitor non-responder: a clinical conundrum
topic Clinical/Narrative Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816276/
https://www.ncbi.nlm.nih.gov/pubmed/26270485
http://dx.doi.org/10.1038/ctg.2015.32
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