Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis b...

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Autores principales: Lanyon-Hogg, Thomas, Masumoto, Naoko, Bodakh, George, Konitsiotis, Antonio D., Thinon, Emmanuelle, Rodgers, Ursula R., Owens, Raymond J., Magee, Anthony I., Tate, Edward W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816282/
https://www.ncbi.nlm.nih.gov/pubmed/27077078
http://dx.doi.org/10.1016/j.dib.2016.02.012
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author Lanyon-Hogg, Thomas
Masumoto, Naoko
Bodakh, George
Konitsiotis, Antonio D.
Thinon, Emmanuelle
Rodgers, Ursula R.
Owens, Raymond J.
Magee, Anthony I.
Tate, Edward W.
author_facet Lanyon-Hogg, Thomas
Masumoto, Naoko
Bodakh, George
Konitsiotis, Antonio D.
Thinon, Emmanuelle
Rodgers, Ursula R.
Owens, Raymond J.
Magee, Anthony I.
Tate, Edward W.
author_sort Lanyon-Hogg, Thomas
collection PubMed
description In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. (1)H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors.
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spelling pubmed-48162822016-04-13 Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase Lanyon-Hogg, Thomas Masumoto, Naoko Bodakh, George Konitsiotis, Antonio D. Thinon, Emmanuelle Rodgers, Ursula R. Owens, Raymond J. Magee, Anthony I. Tate, Edward W. Data Brief Data Article In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis based on their published high potencies against the enzyme target. RU-SKI 41 (9a), RU-SKI 43 (9b), RU-SKI 101 (9c), and RU-SKI 201 (9d) were profiled for activity in the related article “Click chemistry armed enzyme linked immunosorbent assay to measure palmitoylation by Hedgehog acyltransferase” (Lanyon-Hogg et al., 2015) [1]. (1)H NMR spectral data indicate different amide conformational ratios between the RU-SKI inhibitors, as has been observed in other 5-acyl-6,7-dihydrothieno[3,2-c]pyridines. The synthetic and characterisation data supplied in the current article provide validated access to the class of RU-SKI inhibitors. Elsevier 2016-02-10 /pmc/articles/PMC4816282/ /pubmed/27077078 http://dx.doi.org/10.1016/j.dib.2016.02.012 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Lanyon-Hogg, Thomas
Masumoto, Naoko
Bodakh, George
Konitsiotis, Antonio D.
Thinon, Emmanuelle
Rodgers, Ursula R.
Owens, Raymond J.
Magee, Anthony I.
Tate, Edward W.
Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
title Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
title_full Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
title_fullStr Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
title_full_unstemmed Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
title_short Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase
title_sort synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of hedgehog acyltransferase
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816282/
https://www.ncbi.nlm.nih.gov/pubmed/27077078
http://dx.doi.org/10.1016/j.dib.2016.02.012
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