Cargando…

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds. RU-SKI compounds were selected for synthesis b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lanyon-Hogg, Thomas, Masumoto, Naoko, Bodakh, George, Konitsiotis, Antonio D., Thinon, Emmanuelle, Rodgers, Ursula R., Owens, Raymond J., Magee, Anthony I., Tate, Edward W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Data Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816282/ https://www.ncbi.nlm.nih.gov/pubmed/27077078 http://dx.doi.org/10.1016/j.dib.2016.02.012

Ejemplares similares

Click chemistry armed enzyme-linked immunosorbent assay to measure palmitoylation by hedgehog acyltransferase
por: Lanyon-Hogg, Thomas, et al.
Publicado: (2015)

Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells
por: Rodgers, Ursula R., et al.
Publicado: (2016)

Topological Analysis of Hedgehog Acyltransferase, a Multipalmitoylated Transmembrane Protein
por: Konitsiotis, Antonio D., et al.
Publicado: (2015)

Attenuation of Hedgehog Acyltransferase-Catalyzed Sonic Hedgehog Palmitoylation Causes Reduced Signaling, Proliferation and Invasiveness of Human Carcinoma Cells
por: Konitsiotis, Antonios D., et al.
Publicado: (2014)

Structure, mechanism, and inhibition of Hedgehog acyltransferase
por: Coupland, Claire E., et al.
Publicado: (2021)

Photochemical Probe Identification of a Small‐Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)
por: Lanyon‐Hogg, Thomas, et al.
Publicado: (2021)

New chemical probes targeting cholesterylation of Sonic Hedgehog in human cells and zebrafish
por: Ciepla, Paulina, et al.
Publicado: (2014)

Inhibitors of Hedgehog Acyltransferase Block Sonic Hedgehog Signaling
por: Petrova, Elissaveta, et al.
Publicado: (2013)

Hedgehog acyltransferase catalyzes a random sequential reaction and utilizes multiple fatty acyl-CoA substrates
por: Schonbrun, Adina R., et al.
Publicado: (2022)

Global profiling of protein lipidation using chemical proteomic technologies
por: Tate, Edward W, et al.
Publicado: (2015)

Palmitoylation of Hedgehog proteins by Hedgehog acyltransferase: roles in signalling and disease
por: Resh, Marilyn D.
Publicado: (2021)

Acylation-coupled lipophilic induction of polarisation (Acyl-cLIP): a universal assay for lipid transferase and hydrolase enzymes
por: Lanyon-Hogg, Thomas, et al.
Publicado: (2019)

Protein S-acyltransferases and acyl protein thioesterases, regulation executors of protein S-acylation in plants
por: Li, Jincheng, et al.
Publicado: (2022)

Identification of Conserved Regions and Residues within Hedgehog Acyltransferase Critical for Palmitoylation of Sonic Hedgehog
por: Buglino, John A., et al.
Publicado: (2010)

A calcium-dependent acyltransferase that produces N-acyl phosphatidylethanolamines
por: Ogura, Yuji, et al.
Publicado: (2016)

Substrate Specificity of Acyltransferase Domains for Efficient Transfer of Acyl Groups
por: Shen, Jie-Jie, et al.
Publicado: (2018)

2-(2,4-Dichlorophenyl)-9-phenyl-2,3-dihydrothieno[3,2-b]quinoline
por: Balamurugan, K., et al.
Publicado: (2009)

Overexpression of Two New Acyl-CoA:Diacylglycerol Acyltransferase 2-Like Acyl-CoA:Sterol Acyltransferases Enhanced Squalene Accumulation in Aurantiochytrium limacinum
por: Rau, E-Ming, et al.
Publicado: (2022)

Thioesters as Acyl Donors in Biocatalytic Friedel‐Crafts‐type Acylation Catalyzed by Acyltransferase from Pseudomonas Protegens
por: Żądło‐Dobrowolska, Anna, et al.
Publicado: (2019)

Acyltransferases Regulate Oil Quality in Camelina sativa Through Both Acyl Donor and Acyl Acceptor Specificities
por: Lager, Ida, et al.
Publicado: (2020)

Rational Engineered C-Acyltransferase Transforms Sterically Demanding Acyl Donors
por: Żądło-Dobrowolska, Anna, et al.
Publicado: (2019)

Mechanism of Biocatalytic Friedel–Crafts Acylation by Acyltransferase from Pseudomonas protegens
por: Sheng, Xiang, et al.
Publicado: (2019)

In vitro reconstitution of substrate S-acylation by the zDHHC family of protein acyltransferases
por: Elliot Murphy, R., et al.
Publicado: (2022)

Possible Role of Different Yeast and Plant Lysophospholipid:Acyl-CoA Acyltransferases (LPLATs) in Acyl Remodelling of Phospholipids
por: Jasieniecka-Gazarkiewicz, Katarzyna, et al.
Publicado: (2015)

S-Acylation of Proteins of Coronavirus and Influenza Virus: Conservation of Acylation Sites in Animal Viruses and DHHC Acyltransferases in Their Animal Reservoirs
por: Abdulrahman, Dina A., et al.
Publicado: (2021)

Exploration of Dihydrothieno[2,3-c] Isoquinolines As Luminescent Materials and Corrosion Inhibitors
por: Marae, Islam S., et al.
Publicado: (2022)

Mutations in Hedgehog Acyltransferase (Hhat) Perturb Hedgehog Signaling, Resulting in Severe Acrania-Holoprosencephaly-Agnathia Craniofacial Defects
por: Dennis, Jennifer F., et al.
Publicado: (2012)

Transcriptional Regulation of Acyl-CoA:Glycerol-sn-3-Phosphate Acyltransferases
por: Karasawa, Ken, et al.
Publicado: (2019)

HBO1 is a versatile histone acyltransferase critical for promoter histone acylations
por: Xiao, Yanhui, et al.
Publicado: (2021)

Activities of acyl-CoA:diacylglycerol acyltransferase (DGAT) and phospholipid:diacylglycerol acyltransferase (PDAT) in microsomal preparations of developing sunflower and safflower seeds
por: Banaś, Walentyna, et al.
Publicado: (2013)

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA
por: Albesa-Jové, David, et al.
Publicado: (2016)

Molecular basis for acyl carrier protein–ketoreductase interaction in trans-acyltransferase polyketide synthases
por: Passmore, Munro, et al.
Publicado: (2021)

Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases
por: Wang, Tao, et al.
Publicado: (2021)

Ghrelin octanoylation by ghrelin O-acyltransferase: protein acylation impacting metabolic and neuroendocrine signalling
por: Davis, Tasha R., et al.
Publicado: (2021)

Hedgehog Acyltransferase Promotes Uptake of Palmitoyl-CoA across the Endoplasmic Reticulum Membrane
por: Asciolla, James J., et al.
Publicado: (2019)

6-Bromo-N-(6-bromopyridin-2-yl)-N-[4-(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)phenyl]pyridin-2-amine
por: Mitchell, Lauren A., et al.
Publicado: (2014)

Acyl-CoA-dependent and acyl-CoA-independent avocado acyltransferases positively influence oleic acid content in nonseed triacylglycerols
por: Behera, Jyoti, et al.
Publicado: (2023)

The type 2 acyl-CoA:diacylglycerol acyltransferase family of the oleaginous microalga Lobosphaera incisa
por: Zienkiewicz, Krzysztof, et al.
Publicado: (2018)

pHBMT1, a BAHD-family monolignol acyltransferase, mediates lignin acylation in poplar
por: de Vries, Lisanne, et al.
Publicado: (2021)

Erratum: Acyl-CoA-dependent and acyl-CoA-independent avocado acyltransferases positively influence oleic acid content in nonseed triacylglycerols
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_i121a0rp8nf8mj3f8olbsg8jvp