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Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort

Although it is recognized that risks of cardiovascular diseases associated with heart failure develop over the life course, no studies have reported whether life course socioeconomic inequalities exist for heart failure risk. The Medical Research Council’s National Survey of Health and Development w...

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Autores principales: Murray, Emily T., Jones, Rebecca, Thomas, Claudia, Ghosh, Arjun K., Sattar, Naveed, Deanfield, John, Hardy, Rebecca, Kuh, Diana, Hughes, Alun D., Whincup, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816291/
https://www.ncbi.nlm.nih.gov/pubmed/27031846
http://dx.doi.org/10.1371/journal.pone.0152691
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author Murray, Emily T.
Jones, Rebecca
Thomas, Claudia
Ghosh, Arjun K.
Sattar, Naveed
Deanfield, John
Hardy, Rebecca
Kuh, Diana
Hughes, Alun D.
Whincup, Peter
author_facet Murray, Emily T.
Jones, Rebecca
Thomas, Claudia
Ghosh, Arjun K.
Sattar, Naveed
Deanfield, John
Hardy, Rebecca
Kuh, Diana
Hughes, Alun D.
Whincup, Peter
author_sort Murray, Emily T.
collection PubMed
description Although it is recognized that risks of cardiovascular diseases associated with heart failure develop over the life course, no studies have reported whether life course socioeconomic inequalities exist for heart failure risk. The Medical Research Council’s National Survey of Health and Development was used to investigate associations between occupational socioeconomic position during childhood, early adulthood and middle age and measures of cardiac structure [left ventricular (LV) mass index and relative wall thickness (RWT)] and function [systolic: ejection fraction (EF) and midwall fractional shortening (mFS); diastolic: left atrial (LA) volume, E/A ratio and E/e’ ratio)]. Different life course models were compared with a saturated model to ascertain the nature of the relationship between socioeconomic position across the life course and each cardiac marker. Findings showed that models where socioeconomic position accumulated over multiple time points in life provided the best fit for 3 of the 7 cardiac markers: childhood and early adulthood periods for the E/A ratio and E/e’ ratio, and all three life periods for LV mass index. These associations were attenuated by adjustment for adiposity, but were little affected by adjustment for other established or novel cardio-metabolic risk factors. There was no evidence of a relationship between socioeconomic position at any time point and RWT, EF, mFS or LA volume index. In conclusion, socioeconomic position across multiple points of the lifecourse, particularly earlier in life, is an important determinant of some measures of LV structure and function. BMI may be an important mediator of these associations.
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spelling pubmed-48162912016-04-14 Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort Murray, Emily T. Jones, Rebecca Thomas, Claudia Ghosh, Arjun K. Sattar, Naveed Deanfield, John Hardy, Rebecca Kuh, Diana Hughes, Alun D. Whincup, Peter PLoS One Research Article Although it is recognized that risks of cardiovascular diseases associated with heart failure develop over the life course, no studies have reported whether life course socioeconomic inequalities exist for heart failure risk. The Medical Research Council’s National Survey of Health and Development was used to investigate associations between occupational socioeconomic position during childhood, early adulthood and middle age and measures of cardiac structure [left ventricular (LV) mass index and relative wall thickness (RWT)] and function [systolic: ejection fraction (EF) and midwall fractional shortening (mFS); diastolic: left atrial (LA) volume, E/A ratio and E/e’ ratio)]. Different life course models were compared with a saturated model to ascertain the nature of the relationship between socioeconomic position across the life course and each cardiac marker. Findings showed that models where socioeconomic position accumulated over multiple time points in life provided the best fit for 3 of the 7 cardiac markers: childhood and early adulthood periods for the E/A ratio and E/e’ ratio, and all three life periods for LV mass index. These associations were attenuated by adjustment for adiposity, but were little affected by adjustment for other established or novel cardio-metabolic risk factors. There was no evidence of a relationship between socioeconomic position at any time point and RWT, EF, mFS or LA volume index. In conclusion, socioeconomic position across multiple points of the lifecourse, particularly earlier in life, is an important determinant of some measures of LV structure and function. BMI may be an important mediator of these associations. Public Library of Science 2016-03-31 /pmc/articles/PMC4816291/ /pubmed/27031846 http://dx.doi.org/10.1371/journal.pone.0152691 Text en © 2016 Murray et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Murray, Emily T.
Jones, Rebecca
Thomas, Claudia
Ghosh, Arjun K.
Sattar, Naveed
Deanfield, John
Hardy, Rebecca
Kuh, Diana
Hughes, Alun D.
Whincup, Peter
Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort
title Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort
title_full Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort
title_fullStr Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort
title_full_unstemmed Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort
title_short Life Course Socioeconomic Position: Associations with Cardiac Structure and Function at Age 60-64 Years in the 1946 British Birth Cohort
title_sort life course socioeconomic position: associations with cardiac structure and function at age 60-64 years in the 1946 british birth cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816291/
https://www.ncbi.nlm.nih.gov/pubmed/27031846
http://dx.doi.org/10.1371/journal.pone.0152691
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