Identification of a Tumor Specific, Active-Site Mutation in Casein Kinase 1α by Chemical Proteomics

We describe the identification of a novel, tumor-specific missense mutation in the active site of casein kinase 1α (CSNK1A1) using activity-based proteomics. Matched normal and tumor colon samples were analyzed using an ATP acyl phosphate probe in a kinase-targeted LC-MS(2) platform. An anomaly in t...

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Detalles Bibliográficos
Autores principales: Okerberg, Eric S., Hainley, Anna, Brown, Heidi, Aban, Arwin, Alemayehu, Senait, Shih, Ann, Wu, Jane, Patricelli, Matthew P., Kozarich, John W., Nomanbhoy, Tyzoon, Rosenblum, Jonathan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816389/
https://www.ncbi.nlm.nih.gov/pubmed/27031502
http://dx.doi.org/10.1371/journal.pone.0152934

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