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Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature

Cutaneous myopericytoma is a rarely reported mesenchymal neoplasm with a benign biologic behavior. It is seen more commonly in males and typically occurs in adults on the distal extremities. To the best of our knowledge, there are only 13 reports describing 45 cases of cutaneous myopericytoma in the...

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Autores principales: Aung, Phyu P., Goldberg, Lynne J., Mahalingam, Meera, Bhawan, Jag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816429/
https://www.ncbi.nlm.nih.gov/pubmed/27047931
http://dx.doi.org/10.1159/000371875
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author Aung, Phyu P.
Goldberg, Lynne J.
Mahalingam, Meera
Bhawan, Jag
author_facet Aung, Phyu P.
Goldberg, Lynne J.
Mahalingam, Meera
Bhawan, Jag
author_sort Aung, Phyu P.
collection PubMed
description Cutaneous myopericytoma is a rarely reported mesenchymal neoplasm with a benign biologic behavior. It is seen more commonly in males and typically occurs in adults on the distal extremities. To the best of our knowledge, there are only 13 reports describing 45 cases of cutaneous myopericytoma in the literature. The 3 cases in this report expand the clinical presentation and reinforce the histopathologic features of cutaneous myopericytoma. While the clinical presentation in 2 cases (located on the scalp and heel) was in keeping with that reported previously of a slow-growing painless firm nodule, the third case, located on the dorsal wrist, presented as a scaly keratotic nodule. Histopathologic examination of all 3 cases revealed an unencapsulated dermal nodule with concentric perivascular arrangement of plump, spindle-shaped myoid cells admixed with thin-walled blood vessels. Immunohistochemical staining revealed the lesional cells to be actin- (3/3) and caldesmon- (2/3) positive and negative for other smooth muscle markers, compatible with perivascular myopericytic differentiation.
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spelling pubmed-48164292016-04-04 Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature Aung, Phyu P. Goldberg, Lynne J. Mahalingam, Meera Bhawan, Jag Dermatopathology (Basel) Case Studies Cutaneous myopericytoma is a rarely reported mesenchymal neoplasm with a benign biologic behavior. It is seen more commonly in males and typically occurs in adults on the distal extremities. To the best of our knowledge, there are only 13 reports describing 45 cases of cutaneous myopericytoma in the literature. The 3 cases in this report expand the clinical presentation and reinforce the histopathologic features of cutaneous myopericytoma. While the clinical presentation in 2 cases (located on the scalp and heel) was in keeping with that reported previously of a slow-growing painless firm nodule, the third case, located on the dorsal wrist, presented as a scaly keratotic nodule. Histopathologic examination of all 3 cases revealed an unencapsulated dermal nodule with concentric perivascular arrangement of plump, spindle-shaped myoid cells admixed with thin-walled blood vessels. Immunohistochemical staining revealed the lesional cells to be actin- (3/3) and caldesmon- (2/3) positive and negative for other smooth muscle markers, compatible with perivascular myopericytic differentiation. S. Karger AG 2015-02-11 /pmc/articles/PMC4816429/ /pubmed/27047931 http://dx.doi.org/10.1159/000371875 Text en Copyright © 2015 by S. Karger AG, Basel
spellingShingle Case Studies
Aung, Phyu P.
Goldberg, Lynne J.
Mahalingam, Meera
Bhawan, Jag
Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature
title Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature
title_full Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature
title_fullStr Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature
title_full_unstemmed Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature
title_short Cutaneous Myopericytoma: A Report of 3 Cases and Review of the Literature
title_sort cutaneous myopericytoma: a report of 3 cases and review of the literature
topic Case Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816429/
https://www.ncbi.nlm.nih.gov/pubmed/27047931
http://dx.doi.org/10.1159/000371875
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