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S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury

BACKGROUND: Major trauma remains one of the principle causes of disability and death throughout the world. There is currently no satisfactory risk assessment to predict mortality in patients with major trauma. The aim of our study is to examine whether S-100 B protein concentrations correlate with i...

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Autores principales: Pfortmueller, Carmen Andrea, Drexel, Christian, Krähenmann-Müller, Simone, Leichtle, Alexander Benedikt, Fiedler, Georg Martin, Lindner, Gregor, Exadaktylos, Aristomenis Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816449/
https://www.ncbi.nlm.nih.gov/pubmed/27031106
http://dx.doi.org/10.1371/journal.pone.0152822
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author Pfortmueller, Carmen Andrea
Drexel, Christian
Krähenmann-Müller, Simone
Leichtle, Alexander Benedikt
Fiedler, Georg Martin
Lindner, Gregor
Exadaktylos, Aristomenis Konstantinos
author_facet Pfortmueller, Carmen Andrea
Drexel, Christian
Krähenmann-Müller, Simone
Leichtle, Alexander Benedikt
Fiedler, Georg Martin
Lindner, Gregor
Exadaktylos, Aristomenis Konstantinos
author_sort Pfortmueller, Carmen Andrea
collection PubMed
description BACKGROUND: Major trauma remains one of the principle causes of disability and death throughout the world. There is currently no satisfactory risk assessment to predict mortality in patients with major trauma. The aim of our study is to examine whether S-100 B protein concentrations correlate with injury severity and survival in patients with major trauma, with special emphasis on patients without head injury. METHODS: Our retrospective data analysis comprised adult patients admitted to our emergency department between 1.12. 2008 and 31.12 2010 with a suspected major trauma. S-100 B concentrations were routinely assessed in major trauma patients. RESULTS: A total of 27.7% (378) of all patients had major trauma. The median ISS was 24.6 (SD 8.4); 16.6% (63/378) of the patients died. S-100 B concentrations correlated overall with the ISS (p<0.0001). Patients who died had significantly higher S-100 B concentrations than survivors (8.2 μg/l versus 2.2 μg/l, p<0.0001). Polytraumatised patients with and without head trauma did not differ significantly with respect to S-100 B concentration (3.2 μg/l (SD 5.3) versus 2.9 μg/l (SD 3.8), respectively, p = 0.63) or with respect to Injury Severity Score (24.8 (SD 8.6) versus 24.2 (SD 8.1), respectively, p = 0.56). S-100 B concentrations correlated negatively with survival (p<0.0001) in all patients and in both subgroups (p = 0.001 and p = 0.006, respectively) CONCLUSIONS: S-100 concentrations on admission correlate positively with greater injury severity and decreased survival in major trauma patients, independently of the presence of a head injury. S-100 B protein levels at admission in patients with major trauma may therefore be used to assess outcome in all polytraumatised patients. These measurements should be subject to further evaluation.
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spelling pubmed-48164492016-04-14 S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury Pfortmueller, Carmen Andrea Drexel, Christian Krähenmann-Müller, Simone Leichtle, Alexander Benedikt Fiedler, Georg Martin Lindner, Gregor Exadaktylos, Aristomenis Konstantinos PLoS One Research Article BACKGROUND: Major trauma remains one of the principle causes of disability and death throughout the world. There is currently no satisfactory risk assessment to predict mortality in patients with major trauma. The aim of our study is to examine whether S-100 B protein concentrations correlate with injury severity and survival in patients with major trauma, with special emphasis on patients without head injury. METHODS: Our retrospective data analysis comprised adult patients admitted to our emergency department between 1.12. 2008 and 31.12 2010 with a suspected major trauma. S-100 B concentrations were routinely assessed in major trauma patients. RESULTS: A total of 27.7% (378) of all patients had major trauma. The median ISS was 24.6 (SD 8.4); 16.6% (63/378) of the patients died. S-100 B concentrations correlated overall with the ISS (p<0.0001). Patients who died had significantly higher S-100 B concentrations than survivors (8.2 μg/l versus 2.2 μg/l, p<0.0001). Polytraumatised patients with and without head trauma did not differ significantly with respect to S-100 B concentration (3.2 μg/l (SD 5.3) versus 2.9 μg/l (SD 3.8), respectively, p = 0.63) or with respect to Injury Severity Score (24.8 (SD 8.6) versus 24.2 (SD 8.1), respectively, p = 0.56). S-100 B concentrations correlated negatively with survival (p<0.0001) in all patients and in both subgroups (p = 0.001 and p = 0.006, respectively) CONCLUSIONS: S-100 concentrations on admission correlate positively with greater injury severity and decreased survival in major trauma patients, independently of the presence of a head injury. S-100 B protein levels at admission in patients with major trauma may therefore be used to assess outcome in all polytraumatised patients. These measurements should be subject to further evaluation. Public Library of Science 2016-03-31 /pmc/articles/PMC4816449/ /pubmed/27031106 http://dx.doi.org/10.1371/journal.pone.0152822 Text en © 2016 Pfortmueller et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pfortmueller, Carmen Andrea
Drexel, Christian
Krähenmann-Müller, Simone
Leichtle, Alexander Benedikt
Fiedler, Georg Martin
Lindner, Gregor
Exadaktylos, Aristomenis Konstantinos
S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury
title S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury
title_full S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury
title_fullStr S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury
title_full_unstemmed S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury
title_short S-100 B Concentrations Are a Predictor of Decreased Survival in Patients with Major Trauma, Independently of Head Injury
title_sort s-100 b concentrations are a predictor of decreased survival in patients with major trauma, independently of head injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816449/
https://www.ncbi.nlm.nih.gov/pubmed/27031106
http://dx.doi.org/10.1371/journal.pone.0152822
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