Cargando…
Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques
Intravascular delivery of broadly neutralizing antibodies (bnAbs) has shown promise for prevention and treatment of HIV infection. However, multiple IV administrations in geographic locations with poor accessibility to medical care have practical limitations. We have assessed the efficacy of plant-d...
Autores principales: | Rosenberg, Yvonne J., Montefiori, David C., LaBranche, Celia C., Lewis, Mark G., Sack, Markus, Lees, Jonathan P., Jiang, Xiaoming |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816452/ https://www.ncbi.nlm.nih.gov/pubmed/27031108 http://dx.doi.org/10.1371/journal.pone.0152760 |
Ejemplares similares
-
Introduction of the YTE mutation into the non-immunogenic HIV bnAb
PGT121 induces anti-drug antibodies in macaques
por: Rosenberg, Yvonne J., et al.
Publicado: (2019) -
Pharmacokinetics and Immunogenicity of Broadly Neutralizing HIV Monoclonal Antibodies in Macaques
por: Rosenberg, Yvonne, et al.
Publicado: (2015) -
MAb PGT121 protects against mucosal SHIV challenge in macaques at concentrations corresponding to its highly potent in vitro neutralization capacity
por: Moldt, B, et al.
Publicado: (2012) -
The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies
por: Sok, Devin, et al.
Publicado: (2013) -
Anti-Drug Antibodies in Pigtailed Macaques Receiving HIV Broadly Neutralising Antibody PGT121
por: Lee, Wen Shi, et al.
Publicado: (2021)