siRNA Screen Identifies Trafficking Host Factors that Modulate Alphavirus Infection

Little is known about the repertoire of cellular factors involved in the replication of pathogenic alphaviruses. To uncover molecular regulators of alphavirus infection, and to identify candidate drug targets, we performed a high-content imaging-based siRNA screen. We revealed an actin-remodeling pa...

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Detalles Bibliográficos
Autores principales: Radoshitzky, Sheli R., Pegoraro, Gianluca, Chī, Xiǎolì, Dǒng, Lián, Chiang, Chih-Yuan, Jozwick, Lucas, Clester, Jeremiah C., Cooper, Christopher L., Courier, Duane, Langan, David P., Underwood, Knashka, Kuehl, Kathleen A., Sun, Mei G., Caì, Yíngyún, Yú, Shuǐqìng, Burk, Robin, Zamani, Rouzbeh, Kota, Krishna, Kuhn, Jens H., Bavari, Sina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816540/
https://www.ncbi.nlm.nih.gov/pubmed/27031835
http://dx.doi.org/10.1371/journal.ppat.1005466

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