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Redundancy of IL-1 Isoform Signaling and Its Implications for Arterial Remodeling

AIMS: Mice deficient in IL-1 receptor 1 (hence unresponsive to both IL-1 isoforms α and β) have impaired expansive arterial remodeling due to diminished expression of matrix-degrading enzymes, especially MMP-3. Emergence of IL-1 as a target in cardiovascular disease prompted the investigation of the...

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Detalles Bibliográficos
Autores principales:	Beltrami-Moreira, Marina, Vromman, Amélie, Sukhova, Galina K., Folco, Eduardo J., Libby, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816548/ https://www.ncbi.nlm.nih.gov/pubmed/27032103 http://dx.doi.org/10.1371/journal.pone.0152474

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