CD8(+) T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy

Although counteracting innate defenses allows oncolytic viruses (OVs) to better replicate and spread within tumors, CD8(+) T-cells restrict their capacity to trigger systemic anti-tumor immune responses. Herpes simplex virus-1 (HSV-1) evades CD8(+) T-cells by producing ICP47, which limits immune rec...

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Detalles Bibliográficos
Autores principales: Pourchet, Aldo, Fuhrmann, Steven R., Pilones, Karsten A., Demaria, Sandra, Frey, Alan B., Mulvey, Matthew, Mohr, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816761/
https://www.ncbi.nlm.nih.gov/pubmed/27077112
http://dx.doi.org/10.1016/j.ebiom.2016.01.022

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