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Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex

Diffusion magnetic resonance imaging (MRI) allows for the noninvasive in vivo examination of anatomical connections in the human brain, which has an important role in understanding brain function. Validation of this technique is vital, but has proved difficult due to the lack of an adequate gold sta...

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Autores principales: Azadbakht, Hojjatollah, Parkes, Laura M., Haroon, Hamied A., Augath, Mark, Logothetis, Nikos K., de Crespigny, Alex, D'Arceuil, Helen E., Parker, Geoffrey J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816782/
https://www.ncbi.nlm.nih.gov/pubmed/25787833
http://dx.doi.org/10.1093/cercor/bhu326
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author Azadbakht, Hojjatollah
Parkes, Laura M.
Haroon, Hamied A.
Augath, Mark
Logothetis, Nikos K.
de Crespigny, Alex
D'Arceuil, Helen E.
Parker, Geoffrey J. M.
author_facet Azadbakht, Hojjatollah
Parkes, Laura M.
Haroon, Hamied A.
Augath, Mark
Logothetis, Nikos K.
de Crespigny, Alex
D'Arceuil, Helen E.
Parker, Geoffrey J. M.
author_sort Azadbakht, Hojjatollah
collection PubMed
description Diffusion magnetic resonance imaging (MRI) allows for the noninvasive in vivo examination of anatomical connections in the human brain, which has an important role in understanding brain function. Validation of this technique is vital, but has proved difficult due to the lack of an adequate gold standard. In this work, the macaque visual system was used as a model as an extensive body of literature of in vivo and postmortem tracer studies has established a detailed understanding of the underlying connections. We performed probabilistic tractography on high angular resolution diffusion imaging data of 2 ex vivo, in vitro macaque brains. Comparisons were made between identified connections at different thresholds of probabilistic connection “strength,” and with various tracking optimization strategies previously proposed in the literature, and known connections from the detailed visual system wiring map described by Felleman and Van Essen (1991; FVE91). On average, 74% of connections that were identified by FVE91 were reproduced by performing the most successfully optimized probabilistic diffusion MRI tractography. Further comparison with the results of a more recent tracer study ( Markov et al. 2012) suggests that the fidelity of tractography in estimating the presence or absence of interareal connections may be greater than this.
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spelling pubmed-48167822016-04-04 Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex Azadbakht, Hojjatollah Parkes, Laura M. Haroon, Hamied A. Augath, Mark Logothetis, Nikos K. de Crespigny, Alex D'Arceuil, Helen E. Parker, Geoffrey J. M. Cereb Cortex Articles Diffusion magnetic resonance imaging (MRI) allows for the noninvasive in vivo examination of anatomical connections in the human brain, which has an important role in understanding brain function. Validation of this technique is vital, but has proved difficult due to the lack of an adequate gold standard. In this work, the macaque visual system was used as a model as an extensive body of literature of in vivo and postmortem tracer studies has established a detailed understanding of the underlying connections. We performed probabilistic tractography on high angular resolution diffusion imaging data of 2 ex vivo, in vitro macaque brains. Comparisons were made between identified connections at different thresholds of probabilistic connection “strength,” and with various tracking optimization strategies previously proposed in the literature, and known connections from the detailed visual system wiring map described by Felleman and Van Essen (1991; FVE91). On average, 74% of connections that were identified by FVE91 were reproduced by performing the most successfully optimized probabilistic diffusion MRI tractography. Further comparison with the results of a more recent tracer study ( Markov et al. 2012) suggests that the fidelity of tractography in estimating the presence or absence of interareal connections may be greater than this. Oxford University Press 2015-11 2015-03-18 /pmc/articles/PMC4816782/ /pubmed/25787833 http://dx.doi.org/10.1093/cercor/bhu326 Text en © The Author 2015. Published by Oxford University Press http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Azadbakht, Hojjatollah
Parkes, Laura M.
Haroon, Hamied A.
Augath, Mark
Logothetis, Nikos K.
de Crespigny, Alex
D'Arceuil, Helen E.
Parker, Geoffrey J. M.
Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex
title Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex
title_full Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex
title_fullStr Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex
title_full_unstemmed Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex
title_short Validation of High-Resolution Tractography Against In Vivo Tracing in the Macaque Visual Cortex
title_sort validation of high-resolution tractography against in vivo tracing in the macaque visual cortex
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816782/
https://www.ncbi.nlm.nih.gov/pubmed/25787833
http://dx.doi.org/10.1093/cercor/bhu326
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