A Novel Mechanism of Spine Damages in Stroke via DAPK1 and Tau

Synaptic spine loss is one of the major preceding consequences of stroke damages, but its underlying molecular mechanisms remain unknown. Here, we report that a direct interaction of DAPK1 with Tau causes spine loss and subsequently neuronal death in a mouse model with stroke. We found that DAPK1 ph...

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Detalles Bibliográficos
Autores principales: Pei, Lei, Wang, Shan, Jin, Huijuan, Bi, Linlin, Wei, Na, Yan, Honglin, Yang, Xin, Yao, Chengye, Xu, Mengmeng, Shu, Shu, Guo, Yu, Yan, Huanhuan, Wu, Jianhua, Li, Hao, Pang, Pei, Tian, Tian, Tian, Qing, Zhu, Ling-Qiang, Shang, You, Lu, Youming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816799/
https://www.ncbi.nlm.nih.gov/pubmed/25995053
http://dx.doi.org/10.1093/cercor/bhv096
Descripción
Sumario:Synaptic spine loss is one of the major preceding consequences of stroke damages, but its underlying molecular mechanisms remain unknown. Here, we report that a direct interaction of DAPK1 with Tau causes spine loss and subsequently neuronal death in a mouse model with stroke. We found that DAPK1 phosphorylates Tau protein at Ser262 (pS(262)) in cortical neurons of stroke mice. Either genetic deletion of DAPK1 kinase domain (KD) in mice (DAPK1-KD(−/−)) or blocking DAPK1-Tau interaction by systematic application of a membrane permeable peptide protects spine damages and improves neurological functions against stroke insults. Thus, disruption of DAPK1-Tau interaction is a promising strategy in clinical management of stroke.

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