Safety and Upper Respiratory Pharmacokinetics of the Hemagglutinin Stalk-Binding Antibody VIS410 Support Treatment and Prophylaxis Based on Population Modeling of Seasonal Influenza A Outbreaks

BACKGROUND: Seasonal influenza is a major public health concern in vulnerable populations. Here we investigated the safety, tolerability, and pharmacokinetics of a broadly neutralizing monoclonal antibody (VIS410) against Influenza A in a Phase 1 clinical trial. Based on these results and preclinica...

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Detalles Bibliográficos
Autores principales: Wollacott, Andrew M., Boni, Maciej F., Szretter, Kristy J., Sloan, Susan E., Yousofshahi, Mona, Viswanathan, Karthik, Bedard, Sylvain, Hay, Catherine A., Smith, Patrick F., Shriver, Zachary, Trevejo, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816807/
https://www.ncbi.nlm.nih.gov/pubmed/27077121
http://dx.doi.org/10.1016/j.ebiom.2016.02.021

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