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Long‐term patterns of urinary pyroglutamic acid in healthy humans

An investigation of human biological variation in urinary organic acids, including pyroglutamic acid along with 39 other compounds, was previously reported in which levels were determined for 8 weeks in healthy adult subjects. Here, unique, 4‐week‐long physiological trends for one of those compounds...

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Autor principal: Lord, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816898/
https://www.ncbi.nlm.nih.gov/pubmed/26908712
http://dx.doi.org/10.14814/phy2.12706
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author Lord, Richard S.
author_facet Lord, Richard S.
author_sort Lord, Richard S.
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description An investigation of human biological variation in urinary organic acids, including pyroglutamic acid along with 39 other compounds, was previously reported in which levels were determined for 8 weeks in healthy adult subjects. Here, unique, 4‐week‐long physiological trends for one of those compounds, pyroglutamic acid (PGA), are reported. When PGA levels for an individual rose above 40 μg/mg creatinine, 4‐week downward progressions occurred until levels reached values near 15 μg/mg creatinine and the pattern was reversed when levels for an individual were below that level in the early weeks of the study. The pattern was especially prominent among 8 of the 13 menstruating female subjects suggesting a possible association with metabolic stress of the menstrual cycle. However, it also appeared in 3 of the 8 male subjects where other sources of metabolic stress may be present. The menstrual association is consistent with estrogen‐mediated increase in oxidative stress. Since PGA is linked to glutathione turnover, the consistency of extreme values across all individuals displaying the pattern indicates that 15 and 40 μg/mg creatinine may represent limits that trigger shifts in sulfur amino acid metabolism. This is the first observation of approximate month‐long cyclic responses in a glutathione‐related urinary marker in humans.
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spelling pubmed-48168982016-04-14 Long‐term patterns of urinary pyroglutamic acid in healthy humans Lord, Richard S. Physiol Rep Original Research An investigation of human biological variation in urinary organic acids, including pyroglutamic acid along with 39 other compounds, was previously reported in which levels were determined for 8 weeks in healthy adult subjects. Here, unique, 4‐week‐long physiological trends for one of those compounds, pyroglutamic acid (PGA), are reported. When PGA levels for an individual rose above 40 μg/mg creatinine, 4‐week downward progressions occurred until levels reached values near 15 μg/mg creatinine and the pattern was reversed when levels for an individual were below that level in the early weeks of the study. The pattern was especially prominent among 8 of the 13 menstruating female subjects suggesting a possible association with metabolic stress of the menstrual cycle. However, it also appeared in 3 of the 8 male subjects where other sources of metabolic stress may be present. The menstrual association is consistent with estrogen‐mediated increase in oxidative stress. Since PGA is linked to glutathione turnover, the consistency of extreme values across all individuals displaying the pattern indicates that 15 and 40 μg/mg creatinine may represent limits that trigger shifts in sulfur amino acid metabolism. This is the first observation of approximate month‐long cyclic responses in a glutathione‐related urinary marker in humans. John Wiley and Sons Inc. 2016-02-23 /pmc/articles/PMC4816898/ /pubmed/26908712 http://dx.doi.org/10.14814/phy2.12706 Text en © 2016 The Author. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Lord, Richard S.
Long‐term patterns of urinary pyroglutamic acid in healthy humans
title Long‐term patterns of urinary pyroglutamic acid in healthy humans
title_full Long‐term patterns of urinary pyroglutamic acid in healthy humans
title_fullStr Long‐term patterns of urinary pyroglutamic acid in healthy humans
title_full_unstemmed Long‐term patterns of urinary pyroglutamic acid in healthy humans
title_short Long‐term patterns of urinary pyroglutamic acid in healthy humans
title_sort long‐term patterns of urinary pyroglutamic acid in healthy humans
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816898/
https://www.ncbi.nlm.nih.gov/pubmed/26908712
http://dx.doi.org/10.14814/phy2.12706
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