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Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors

Protein-protein interactions (PPIs) play vital roles in life and provide new opportunities for therapeutic interventions. In this large data analysis, 3,300 inhibitors of PPIs (iPPIs) were compared to 17 reference datasets of collectively ~566,000 compounds (including natural compounds, existing dru...

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Detalles Bibliográficos
Autores principales:	Kuenemann, Mélaine A., Labbé, Céline M., Cerdan, Adrien H., Sperandio, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817116/ https://www.ncbi.nlm.nih.gov/pubmed/27034268 http://dx.doi.org/10.1038/srep23815

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