A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion

Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with poor prognosis and its incidence is increasing worldwide. Recently, several types of cells have been considered as the origin of ICC, namely cholangiocytes, liver progenitor cells, and hepatocytes. Here, we have established a nov...

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Detalles Bibliográficos
Autores principales: Ikenoue, Tsuneo, Terakado, Yumi, Nakagawa, Hayato, Hikiba, Yohko, Fujii, Tomoaki, Matsubara, Daisuke, Noguchi, Rei, Zhu, Chi, Yamamoto, Keisuke, Kudo, Yotaro, Asaoka, Yoshinari, Yamaguchi, Kiyoshi, Ijichi, Hideaki, Tateishi, Keisuke, Fukushima, Noriyoshi, Maeda, Shin, Koike, Kazuhiko, Furukawa, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817147/
https://www.ncbi.nlm.nih.gov/pubmed/27032374
http://dx.doi.org/10.1038/srep23899

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