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Recent advances of biomaterials in biotherapy
Biotherapy mainly refers to the intervention and the treatment of major diseases with biotechnologies or bio-drugs, which include gene therapy, immunotherapy (vaccines and antibodies), bone marrow transplantation and stem-cell therapy. In recent years, numerous biomaterials have emerged and were uti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817323/ https://www.ncbi.nlm.nih.gov/pubmed/27047675 http://dx.doi.org/10.1093/rb/rbw007 |
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author | Li, Ling He, Zhi-Yao Wei, Xia-Wei Wei, Yu-Quan |
author_facet | Li, Ling He, Zhi-Yao Wei, Xia-Wei Wei, Yu-Quan |
author_sort | Li, Ling |
collection | PubMed |
description | Biotherapy mainly refers to the intervention and the treatment of major diseases with biotechnologies or bio-drugs, which include gene therapy, immunotherapy (vaccines and antibodies), bone marrow transplantation and stem-cell therapy. In recent years, numerous biomaterials have emerged and were utilized in the field of biotherapy due to their biocompatibility and biodegradability. Generally, biomaterials can be classified into natural or synthetic polymers according to their source, both of which have attracted much attention. Notably, biomaterials-based non-viral gene delivery vectors in gene therapy are undergoing rapid development with the emergence of surface-modified or functionalized materials. In immunotherapy, biomaterials appear to be attractive means for enhancing the delivery efficacy and the potency of vaccines. Additionally, hydrogels and scaffolds are ideal candidates in stem-cell therapy and tissue engineering. In this review, we present an introduction of biomaterials used in above biotherapy, including gene therapy, immunotherapy, stem-cell therapy and tissue engineering. We also highlighted the biomaterials which have already entered the clinical evaluation |
format | Online Article Text |
id | pubmed-4817323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48173232016-04-04 Recent advances of biomaterials in biotherapy Li, Ling He, Zhi-Yao Wei, Xia-Wei Wei, Yu-Quan Regen Biomater Reviews Biotherapy mainly refers to the intervention and the treatment of major diseases with biotechnologies or bio-drugs, which include gene therapy, immunotherapy (vaccines and antibodies), bone marrow transplantation and stem-cell therapy. In recent years, numerous biomaterials have emerged and were utilized in the field of biotherapy due to their biocompatibility and biodegradability. Generally, biomaterials can be classified into natural or synthetic polymers according to their source, both of which have attracted much attention. Notably, biomaterials-based non-viral gene delivery vectors in gene therapy are undergoing rapid development with the emergence of surface-modified or functionalized materials. In immunotherapy, biomaterials appear to be attractive means for enhancing the delivery efficacy and the potency of vaccines. Additionally, hydrogels and scaffolds are ideal candidates in stem-cell therapy and tissue engineering. In this review, we present an introduction of biomaterials used in above biotherapy, including gene therapy, immunotherapy, stem-cell therapy and tissue engineering. We also highlighted the biomaterials which have already entered the clinical evaluation Oxford University Press 2016-06 2016-03-05 /pmc/articles/PMC4817323/ /pubmed/27047675 http://dx.doi.org/10.1093/rb/rbw007 Text en © The Author(s) 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Li, Ling He, Zhi-Yao Wei, Xia-Wei Wei, Yu-Quan Recent advances of biomaterials in biotherapy |
title | Recent advances of biomaterials in biotherapy |
title_full | Recent advances of biomaterials in biotherapy |
title_fullStr | Recent advances of biomaterials in biotherapy |
title_full_unstemmed | Recent advances of biomaterials in biotherapy |
title_short | Recent advances of biomaterials in biotherapy |
title_sort | recent advances of biomaterials in biotherapy |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817323/ https://www.ncbi.nlm.nih.gov/pubmed/27047675 http://dx.doi.org/10.1093/rb/rbw007 |
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