Cargando…

Regeneration strategies after the adult mammalian central nervous system injury—biomaterials

The central nervous system (CNS) has very restricted intrinsic regeneration ability under the injury or disease condition. Innovative repair strategies, therefore, are urgently needed to facilitate tissue regeneration and functional recovery. The published tissue repair/regeneration strategies, such...

Descripción completa

Detalles Bibliográficos
Autores principales: Gao, Yudan, Yang, Zhaoyang, Li, Xiaoguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817328/
https://www.ncbi.nlm.nih.gov/pubmed/27047678
http://dx.doi.org/10.1093/rb/rbw004
_version_ 1782424875242094592
author Gao, Yudan
Yang, Zhaoyang
Li, Xiaoguang
author_facet Gao, Yudan
Yang, Zhaoyang
Li, Xiaoguang
author_sort Gao, Yudan
collection PubMed
description The central nervous system (CNS) has very restricted intrinsic regeneration ability under the injury or disease condition. Innovative repair strategies, therefore, are urgently needed to facilitate tissue regeneration and functional recovery. The published tissue repair/regeneration strategies, such as cell and/or drug delivery, has been demonstrated to have some therapeutic effects on experimental animal models, but can hardly find clinical applications due to such methods as the extremely low survival rate of transplanted cells, difficulty in integrating with the host or restriction of blood–brain barriers to administration patterns. Using biomaterials can not only increase the survival rate of grafts and their integration with the host in the injured CNS area, but also sustainably deliver bioproducts to the local injured area, thus improving the microenvironment in that area. This review mainly introduces the advances of various strategies concerning facilitating CNS regeneration.
format Online
Article
Text
id pubmed-4817328
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-48173282016-04-04 Regeneration strategies after the adult mammalian central nervous system injury—biomaterials Gao, Yudan Yang, Zhaoyang Li, Xiaoguang Regen Biomater Reviews The central nervous system (CNS) has very restricted intrinsic regeneration ability under the injury or disease condition. Innovative repair strategies, therefore, are urgently needed to facilitate tissue regeneration and functional recovery. The published tissue repair/regeneration strategies, such as cell and/or drug delivery, has been demonstrated to have some therapeutic effects on experimental animal models, but can hardly find clinical applications due to such methods as the extremely low survival rate of transplanted cells, difficulty in integrating with the host or restriction of blood–brain barriers to administration patterns. Using biomaterials can not only increase the survival rate of grafts and their integration with the host in the injured CNS area, but also sustainably deliver bioproducts to the local injured area, thus improving the microenvironment in that area. This review mainly introduces the advances of various strategies concerning facilitating CNS regeneration. Oxford University Press 2016-06 2016-03-08 /pmc/articles/PMC4817328/ /pubmed/27047678 http://dx.doi.org/10.1093/rb/rbw004 Text en © The Author(s) 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Gao, Yudan
Yang, Zhaoyang
Li, Xiaoguang
Regeneration strategies after the adult mammalian central nervous system injury—biomaterials
title Regeneration strategies after the adult mammalian central nervous system injury—biomaterials
title_full Regeneration strategies after the adult mammalian central nervous system injury—biomaterials
title_fullStr Regeneration strategies after the adult mammalian central nervous system injury—biomaterials
title_full_unstemmed Regeneration strategies after the adult mammalian central nervous system injury—biomaterials
title_short Regeneration strategies after the adult mammalian central nervous system injury—biomaterials
title_sort regeneration strategies after the adult mammalian central nervous system injury—biomaterials
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817328/
https://www.ncbi.nlm.nih.gov/pubmed/27047678
http://dx.doi.org/10.1093/rb/rbw004
work_keys_str_mv AT gaoyudan regenerationstrategiesaftertheadultmammaliancentralnervoussysteminjurybiomaterials
AT yangzhaoyang regenerationstrategiesaftertheadultmammaliancentralnervoussysteminjurybiomaterials
AT lixiaoguang regenerationstrategiesaftertheadultmammaliancentralnervoussysteminjurybiomaterials