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Regeneration strategies after the adult mammalian central nervous system injury—biomaterials
The central nervous system (CNS) has very restricted intrinsic regeneration ability under the injury or disease condition. Innovative repair strategies, therefore, are urgently needed to facilitate tissue regeneration and functional recovery. The published tissue repair/regeneration strategies, such...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817328/ https://www.ncbi.nlm.nih.gov/pubmed/27047678 http://dx.doi.org/10.1093/rb/rbw004 |
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author | Gao, Yudan Yang, Zhaoyang Li, Xiaoguang |
author_facet | Gao, Yudan Yang, Zhaoyang Li, Xiaoguang |
author_sort | Gao, Yudan |
collection | PubMed |
description | The central nervous system (CNS) has very restricted intrinsic regeneration ability under the injury or disease condition. Innovative repair strategies, therefore, are urgently needed to facilitate tissue regeneration and functional recovery. The published tissue repair/regeneration strategies, such as cell and/or drug delivery, has been demonstrated to have some therapeutic effects on experimental animal models, but can hardly find clinical applications due to such methods as the extremely low survival rate of transplanted cells, difficulty in integrating with the host or restriction of blood–brain barriers to administration patterns. Using biomaterials can not only increase the survival rate of grafts and their integration with the host in the injured CNS area, but also sustainably deliver bioproducts to the local injured area, thus improving the microenvironment in that area. This review mainly introduces the advances of various strategies concerning facilitating CNS regeneration. |
format | Online Article Text |
id | pubmed-4817328 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48173282016-04-04 Regeneration strategies after the adult mammalian central nervous system injury—biomaterials Gao, Yudan Yang, Zhaoyang Li, Xiaoguang Regen Biomater Reviews The central nervous system (CNS) has very restricted intrinsic regeneration ability under the injury or disease condition. Innovative repair strategies, therefore, are urgently needed to facilitate tissue regeneration and functional recovery. The published tissue repair/regeneration strategies, such as cell and/or drug delivery, has been demonstrated to have some therapeutic effects on experimental animal models, but can hardly find clinical applications due to such methods as the extremely low survival rate of transplanted cells, difficulty in integrating with the host or restriction of blood–brain barriers to administration patterns. Using biomaterials can not only increase the survival rate of grafts and their integration with the host in the injured CNS area, but also sustainably deliver bioproducts to the local injured area, thus improving the microenvironment in that area. This review mainly introduces the advances of various strategies concerning facilitating CNS regeneration. Oxford University Press 2016-06 2016-03-08 /pmc/articles/PMC4817328/ /pubmed/27047678 http://dx.doi.org/10.1093/rb/rbw004 Text en © The Author(s) 2016. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Gao, Yudan Yang, Zhaoyang Li, Xiaoguang Regeneration strategies after the adult mammalian central nervous system injury—biomaterials |
title | Regeneration strategies after the adult mammalian central nervous system injury—biomaterials |
title_full | Regeneration strategies after the adult mammalian central nervous system injury—biomaterials |
title_fullStr | Regeneration strategies after the adult mammalian central nervous system injury—biomaterials |
title_full_unstemmed | Regeneration strategies after the adult mammalian central nervous system injury—biomaterials |
title_short | Regeneration strategies after the adult mammalian central nervous system injury—biomaterials |
title_sort | regeneration strategies after the adult mammalian central nervous system injury—biomaterials |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817328/ https://www.ncbi.nlm.nih.gov/pubmed/27047678 http://dx.doi.org/10.1093/rb/rbw004 |
work_keys_str_mv | AT gaoyudan regenerationstrategiesaftertheadultmammaliancentralnervoussysteminjurybiomaterials AT yangzhaoyang regenerationstrategiesaftertheadultmammaliancentralnervoussysteminjurybiomaterials AT lixiaoguang regenerationstrategiesaftertheadultmammaliancentralnervoussysteminjurybiomaterials |