Cargando…
Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population
BACKGROUND: Oxidative stress is considered as an initial pathogenic event in melanocyte destruction. These free radicals are scavenged by antioxidants, whose sum of activity in serum is measured by total antioxidant status (TAS). In addition, homocysteine (Hcy) may mediate melanocyte destruction via...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817435/ https://www.ncbi.nlm.nih.gov/pubmed/27057010 http://dx.doi.org/10.4103/0019-5154.177764 |
_version_ | 1782424885704785920 |
---|---|
author | Gupta, Shikha D'souza, Paschal Dhali, Tapan Kumar Arora, Sarika |
author_facet | Gupta, Shikha D'souza, Paschal Dhali, Tapan Kumar Arora, Sarika |
author_sort | Gupta, Shikha |
collection | PubMed |
description | BACKGROUND: Oxidative stress is considered as an initial pathogenic event in melanocyte destruction. These free radicals are scavenged by antioxidants, whose sum of activity in serum is measured by total antioxidant status (TAS). In addition, homocysteine (Hcy) may mediate melanocyte destruction via increased oxidative damage. However, previous studies investigating these parameters in vitiligo provide equivocal results. AIMS: To study and compare serum Hcy and TAS levels in vitiligo patients with controls and also to correlate these parameters with the various disease characteristics. The present study further looked into any correlation between serum Hcy and TAS in vitiligo. MATERIALS AND METHODS: A case control study was conducted on 82 vitiligo patients and 83 controls aged 18–45 years after excluding factors which could potentially alter serum Hcy or TAS levels. Disease characteristics were studied and blood samples were obtained for measuring serum Hcy and TAS levels. RESULTS: TAS levels were lower in vitiligo patients than controls (1.79 ± 0.51 vs. 2.16 ± 0.63 mmol/L; P < 0.001) and had a negative correlation with disease activity (r = −0.410, P < 0.001). However, serum Hcy levels were comparable between vitiligo patients (18.68 ± 9.90 μmol/L) and controls (20.21 ± 13.39 μmol/L) (P = 0.406). No significant correlation was found between serum Hcy and serum TAS levels. CONCLUSIONS: Serum TAS may be further investigated to establish its role as biomarker for vitiligo since its levels also correlate with disease activity. However, serum Hcy may not be a reliable marker in Indian population probably because of differences in dietary habits. |
format | Online Article Text |
id | pubmed-4817435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48174352016-04-07 Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population Gupta, Shikha D'souza, Paschal Dhali, Tapan Kumar Arora, Sarika Indian J Dermatol Basic Research BACKGROUND: Oxidative stress is considered as an initial pathogenic event in melanocyte destruction. These free radicals are scavenged by antioxidants, whose sum of activity in serum is measured by total antioxidant status (TAS). In addition, homocysteine (Hcy) may mediate melanocyte destruction via increased oxidative damage. However, previous studies investigating these parameters in vitiligo provide equivocal results. AIMS: To study and compare serum Hcy and TAS levels in vitiligo patients with controls and also to correlate these parameters with the various disease characteristics. The present study further looked into any correlation between serum Hcy and TAS in vitiligo. MATERIALS AND METHODS: A case control study was conducted on 82 vitiligo patients and 83 controls aged 18–45 years after excluding factors which could potentially alter serum Hcy or TAS levels. Disease characteristics were studied and blood samples were obtained for measuring serum Hcy and TAS levels. RESULTS: TAS levels were lower in vitiligo patients than controls (1.79 ± 0.51 vs. 2.16 ± 0.63 mmol/L; P < 0.001) and had a negative correlation with disease activity (r = −0.410, P < 0.001). However, serum Hcy levels were comparable between vitiligo patients (18.68 ± 9.90 μmol/L) and controls (20.21 ± 13.39 μmol/L) (P = 0.406). No significant correlation was found between serum Hcy and serum TAS levels. CONCLUSIONS: Serum TAS may be further investigated to establish its role as biomarker for vitiligo since its levels also correlate with disease activity. However, serum Hcy may not be a reliable marker in Indian population probably because of differences in dietary habits. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4817435/ /pubmed/27057010 http://dx.doi.org/10.4103/0019-5154.177764 Text en Copyright: © 2016 Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Basic Research Gupta, Shikha D'souza, Paschal Dhali, Tapan Kumar Arora, Sarika Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population |
title | Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population |
title_full | Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population |
title_fullStr | Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population |
title_full_unstemmed | Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population |
title_short | Serum Homocysteine and Total Antioxidant Status in Vitiligo: A Case Control Study in Indian Population |
title_sort | serum homocysteine and total antioxidant status in vitiligo: a case control study in indian population |
topic | Basic Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817435/ https://www.ncbi.nlm.nih.gov/pubmed/27057010 http://dx.doi.org/10.4103/0019-5154.177764 |
work_keys_str_mv | AT guptashikha serumhomocysteineandtotalantioxidantstatusinvitiligoacasecontrolstudyinindianpopulation AT dsouzapaschal serumhomocysteineandtotalantioxidantstatusinvitiligoacasecontrolstudyinindianpopulation AT dhalitapankumar serumhomocysteineandtotalantioxidantstatusinvitiligoacasecontrolstudyinindianpopulation AT arorasarika serumhomocysteineandtotalantioxidantstatusinvitiligoacasecontrolstudyinindianpopulation |