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Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up?

BACKGROUND: Primary axillary hyperhidrosis (PAH) is a chronic idiopathic disorder causing major stress in patients. Among the common therapies for PAH, only surgical interventions have proven feasible as a permanent solution. OBJECTIVE AND AIM: The aim of this study was to evaluate the efficacy and...

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Autores principales: Abtahi-Naeini, Bahareh, Naeini, Farahnaz Fatemi, Saffaei, Ali, Behfar, Shadi, Pourazizi, Mohsen, Mirmohammadkhani, Majid, Bolandnazar, Najmeh-Sadat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817464/
https://www.ncbi.nlm.nih.gov/pubmed/27057039
http://dx.doi.org/10.4103/0019-5154.177789
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author Abtahi-Naeini, Bahareh
Naeini, Farahnaz Fatemi
Saffaei, Ali
Behfar, Shadi
Pourazizi, Mohsen
Mirmohammadkhani, Majid
Bolandnazar, Najmeh-Sadat
author_facet Abtahi-Naeini, Bahareh
Naeini, Farahnaz Fatemi
Saffaei, Ali
Behfar, Shadi
Pourazizi, Mohsen
Mirmohammadkhani, Majid
Bolandnazar, Najmeh-Sadat
author_sort Abtahi-Naeini, Bahareh
collection PubMed
description BACKGROUND: Primary axillary hyperhidrosis (PAH) is a chronic idiopathic disorder causing major stress in patients. Among the common therapies for PAH, only surgical interventions have proven feasible as a permanent solution. OBJECTIVE AND AIM: The aim of this study was to evaluate the efficacy and safety of fractional microneedle radiofrequency (FMR) as an alternative permanent treatment for PAH with long-term follow-up. MATERIALS AND METHODS: This was a single-blind, sham-controlled comparative study. Twenty-five patients with severe PAH were provided three treatments of FMR at 3-week intervals (the treatment group), and a control group was provided the sham treatment. Clinical efficacy was evaluated using the hyperhidrosis disease severity scale (HDSS) at baseline and the end of the study, as well as during the 1 year follow-up phase. RESULTS: HDSS demonstrated significant improvement after treatment in the treatment group compared to the sham control. The mean (±standard deviation) of HDSS in the group being treated with radiofrequency was 2.50 (±0.88) after 1 year follow-up, and that of the control group was 3.38 (±0.49; P < 0.001). Follow-up results show that there were 10 patients (41.6%) with no relapse and 11 patients (45.9%) with relapse after 1 year. There was a significant correlation between HDSS changes in relapse and body mass index (BMI) (P = 0.03). CONCLUSION: Treatment of PAH with FMR is a safe and noninvasive procedure with a positive therapeutic effect on HDSS. It is recommended, however, that sessions of FMR be repeated after 1 year, particularly in overweight patients with high BMIs. CLINICAL TRIAL REGISTRATION: IRCT2013111915455N1. LEVEL OF EVIDENCES: Level II-1.
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spelling pubmed-48174642016-04-07 Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up? Abtahi-Naeini, Bahareh Naeini, Farahnaz Fatemi Saffaei, Ali Behfar, Shadi Pourazizi, Mohsen Mirmohammadkhani, Majid Bolandnazar, Najmeh-Sadat Indian J Dermatol E-IJD Original Article BACKGROUND: Primary axillary hyperhidrosis (PAH) is a chronic idiopathic disorder causing major stress in patients. Among the common therapies for PAH, only surgical interventions have proven feasible as a permanent solution. OBJECTIVE AND AIM: The aim of this study was to evaluate the efficacy and safety of fractional microneedle radiofrequency (FMR) as an alternative permanent treatment for PAH with long-term follow-up. MATERIALS AND METHODS: This was a single-blind, sham-controlled comparative study. Twenty-five patients with severe PAH were provided three treatments of FMR at 3-week intervals (the treatment group), and a control group was provided the sham treatment. Clinical efficacy was evaluated using the hyperhidrosis disease severity scale (HDSS) at baseline and the end of the study, as well as during the 1 year follow-up phase. RESULTS: HDSS demonstrated significant improvement after treatment in the treatment group compared to the sham control. The mean (±standard deviation) of HDSS in the group being treated with radiofrequency was 2.50 (±0.88) after 1 year follow-up, and that of the control group was 3.38 (±0.49; P < 0.001). Follow-up results show that there were 10 patients (41.6%) with no relapse and 11 patients (45.9%) with relapse after 1 year. There was a significant correlation between HDSS changes in relapse and body mass index (BMI) (P = 0.03). CONCLUSION: Treatment of PAH with FMR is a safe and noninvasive procedure with a positive therapeutic effect on HDSS. It is recommended, however, that sessions of FMR be repeated after 1 year, particularly in overweight patients with high BMIs. CLINICAL TRIAL REGISTRATION: IRCT2013111915455N1. LEVEL OF EVIDENCES: Level II-1. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC4817464/ /pubmed/27057039 http://dx.doi.org/10.4103/0019-5154.177789 Text en Copyright: © 2016 Indian Journal of Dermatology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle E-IJD Original Article
Abtahi-Naeini, Bahareh
Naeini, Farahnaz Fatemi
Saffaei, Ali
Behfar, Shadi
Pourazizi, Mohsen
Mirmohammadkhani, Majid
Bolandnazar, Najmeh-Sadat
Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up?
title Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up?
title_full Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up?
title_fullStr Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up?
title_full_unstemmed Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up?
title_short Treatment of Primary Axillary Hyperhidrosis by Fractional Microneedle Radiofrequency: Is it Still Effective after Long-term Follow-up?
title_sort treatment of primary axillary hyperhidrosis by fractional microneedle radiofrequency: is it still effective after long-term follow-up?
topic E-IJD Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817464/
https://www.ncbi.nlm.nih.gov/pubmed/27057039
http://dx.doi.org/10.4103/0019-5154.177789
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