A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1

Splicing aberrations are prominent drivers of cancer, yet the regulatory pathways controlling them are mostly unknown. Here we develop a method that integrates physical interaction, gene expression, and alternative splicing data to construct the largest map of transcriptomic and proteomic interactio...

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Detalles Bibliográficos
Autores principales: Hollander, Dror, Donyo, Maya, Atias, Nir, Mekahel, Keren, Melamed, Zeev, Yannai, Sivan, Lev-Maor, Galit, Shilo, Asaf, Schwartz, Schraga, Barshack, Iris, Sharan, Roded, Ast, Gil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817777/
https://www.ncbi.nlm.nih.gov/pubmed/26860615
http://dx.doi.org/10.1101/gr.193169.115

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