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Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease

OBJECTIVE: The genetic risk architecture of Alzheimer disease (AD) is complex with single pathogenic mutations leading to early-onset AD, while both rare and common genetic susceptibility variants contribute to the more widespread late-onset AD (LOAD); we sought to discover novel genes contributing...

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Detalles Bibliográficos
Autores principales:	Kohli, Martin A., Cukier, Holly N., Hamilton-Nelson, Kara L., Rolati, Sophie, Kunkle, Brian W., Whitehead, Patrice L., Züchner, Stephan L., Farrer, Lindsay A., Martin, Eden R., Beecham, Gary W., Haines, Jonathan L., Vance, Jeffery M., Cuccaro, Michael L., Gilbert, John R., Schellenberg, Gerard D., Carney, Regina M., Pericak-Vance, Margaret A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wolters Kluwer 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817909/ https://www.ncbi.nlm.nih.gov/pubmed/27066578 http://dx.doi.org/10.1212/NXG.0000000000000041

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